白藜芦醇在炎症性肠病中的研究进展  

Advances in Studies on Resveratrol in Inflammatory Bowel Disease

作　　者：李平[1] 林琳[1] 

机构地区：[1]南京医科大学第一附属医院消化内科,210029

出　　处：《胃肠病学》2014年第3期173-176,共4页Chinese Journal of Gastroenterology

基　　金：江苏省科技创新与成果转化(重大科技支撑与自主创新)专项引导资金资助(BZ2011044)

摘　　要：炎症性肠病(IBD)是一类病因不明的肠道慢性非特异性炎症性疾病。白藜芦醇(RSV)是一种提取自红葡萄酒的天然多酚类化合物,其为NAD+依赖的组蛋白去乙酰化酶SIRT1激动剂,具有抗氧化、抗炎、抗肿瘤、抗纤维化等多种生物学活性。RSV在IBD中的作用主要包括抗炎和抗纤维化两个方面,本文就其在IBD中的研究进展作一综述。Inflammatory bowel disease （IBD） is characterized by chronic non-specific intestinal inflammation with unknown etiology. Resveratrol, a natural polyphenol compound found in red wine, is an agonist of SIRT1 （ a NAD ＋ - dependent histone deacetylase）, and has been shown to have antioxidant, antiinflammatory, antitumor and antifibrogenic activities. The main effect of resveratrol in IBD is against inflammation and fibrogenesis. In this review article, the advances in studies on resveratrol in IBD were summarized.

关 键 词：炎症性肠病 白藜芦醇 SIRT1 炎症 NF-ΚB 纤维化 

分 类 号：R574[医药卫生—消化系统]