口腔扁平苔藓组织中HERG1和Kv3.4钾离子通道蛋白的表达  

Expression of HERG1 and Kv3.4 in oral lichen planus

作　　者：缪克红[1] 聂敏海[2] 宋成成[2] 宋萍萍[2] 伍宝琴[2] 

机构地区：[1]自贡市第一人民医院口腔科,643000 [2]泸州医学院附属口腔医院口腔内科

出　　处：《实用口腔医学杂志》2014年第2期206-210,共5页Journal of Practical Stomatology

摘　　要：目的:研究钾离子通道蛋白HERG1、Kv3.4在口腔扁平苔藓(oral lichen planus,OLP)中的表达及意义。方法:采用免疫组织化学SP技术检测20例OLP和16例正常口腔黏膜(normal oral mucosa,NOM)组织中HERG1及Kv3.4的表达。结果:HERG1和Kv3.4在NOM、非糜烂型OLP组织表达阴性或基底层有少量表达;在糜烂型OLP基底层、棘细胞层及颗粒层呈阳性表达;HERG1、Kv3.4在OLP组织的表达均高于正常组织(P<0.05),且糜烂型OLP中的表达高于非糜烂型OLP(P<0.05);在OLP中HERG1与Kv3.4的表达呈正相关(P<0.05)。结论:HERG1、Kv3.4可能与OLP的发生发展有关。Objective：To investigate the expression of HERG1 and Kv3.4 in normal oral mucosa（NOM）and oral lichen planus （OLP）.Methods：20 OLP and 1 6 NOM specimens were collected and immunohistochemically stained（IHC）by SP method for the detection of HERG1 and Kv3.4 protein expression.Results：HERG1 and Kv3.4 were negative or weak-positive in the sapmles of bas-al layer of NOMand non-erosive OLP,but positive in basal layer,spinous layer and granular layer of erosive OLP.The expression of HERG1 and Kv3.4 was higher in OLP than in NOM tissues （P 〈0.05）;and higher in erosive OLP than in non-erosive OLP（P 〈0.05）.In OLP HERG1 expression was positively related to Kv3.4（P 〈0.05）.Conclusion：HERG1 and Kv3.4 may be related to the development of OLP.

关 键 词：口腔扁平苔藓 HERG1 Kv3 4 钾离子通道 

分 类 号：R781.5[医药卫生—口腔医学]