人博卡病毒I型的研究进展  

Progress on Development and Research of Human Bocavirus 1

作　　者：崔换弟 金玉[2] 谢广成[3] 段招军[3] 

机构地区：[1]兰州大学第一医院,兰州730000 [2]南京医科大学附属南京儿童医院,南京210008 [3]中国疾病预防控制中心病毒病预防控制所,北京102206

出　　处：《病毒学报》2014年第1期103-108,共6页Chinese Journal of Virology

摘　　要：人博卡病毒1型(HBoV1)为引发呼吸道感染一种新发病毒,具有典型的细小病毒科病毒基因组特征,3个开放阅读框分别编码非结构蛋白NS1、NP1和结构蛋白VP1和VP2;HBoV1进行滚环复制时存在复制环形附加体,附加体的发现为扩增HBoV1全基因组和构建感染性克隆拯救病毒提供可能,同时HBoV1与HBoV2-4间存在着重组关系;HBoV1的体外增殖随着三维立体细胞培养而成为现实,为HBoV1的致病机制研究提供有力平台。本文重点对HBoV1的分子生物学特征、疾病相关性、体外增殖培养、HBoV1的诊断和治疗进行阐述。Abstract： Human bocavirus 1 （HBoV1） is a novel virus that mainly causes respiratory tract infection, and it has the characteristic of genome of Parvovirus, containing three open reading frames that encode nonstructural proteins NS1 and NP1 and structural proteins VP1 and VP2. Circular episome is present during the rolling circle replication of HBoV1, which provides the possibility of full genome amplification and infectious clone construction to save HBoV1. The recombination between HBoV1 and HBoV2-4 occurs frequently. With the three-dimensional culture, in vitro culture of HBoV1 provides a powerful tool for research on the pathogenesis of HBoV1. This review focuses on the molecular characteristics, association with diseases, in vitro culture, diagnosis and treatment of HBoV1.

关 键 词：人博卡病毒1 环形附加体 疾病相关性 三维培养 

分 类 号：R373.9[医药卫生—病原生物学]