二次经尿道等离子体电切术降低中高危非肌层浸润性膀胱癌术后复发的临床研究  

Clinical study on repeat transurethral plasmakinetic resection of the bladder tumor in preventing the recurrence of the high risk non muscle invasive bladder cancer

作　　者：高伟[1] 刘建平[1] 王永忠[1] 梁胜军[1] 殷振超[1] 周红艳[1] 阮建民[1] 

机构地区：[1]广州医学院荔湾医院泌尿外科,510000

出　　处：《国际医药卫生导报》2014年第7期924-927,共4页International Medicine and Health Guidance News

摘　　要：目的 探讨二次经尿道等离子体电切术（PKRBT）降低中高危非肌层浸润性膀胱癌术后肿瘤复发率的临床研究.方法 选取2010年1月至2012年4月已经行第一次PKRBT的中高危非肌层浸润性膀胱癌患者62例,随机分为实验组和对照组,实验组于第一次PKRBT术后4～6周行二次PKRBT,两组均在PKRBT术后开始辅助性膀胱灌注化疗;每三个月返院复查膀胱镜一次,两组均随访20个月,评估两组肿瘤复发率.结果 随访20个月,实验组复发率19.4％,对照组复发率41.9％,实验组复发率较对照组显著降低,差异有统计学意义（P＜0.05）.结论 中高危非肌层浸润性膀胱癌患者行二次经尿道等离子体电切术及术后辅助性膀胱灌注化疗,能有效降低肿瘤复发率,并可获得更准确的病理分期.Objective To assess the clinical study of the repeat transurethral plasmakinetic resection of the bladder tumor （PKRBT） in preventing the recurrence rate of the high risk non muscle invasive bladder cancer （NMIBC）.Methods 62 cases of high risk NMIBC treated by the first PKRBT were selected as the study objects from January 2010 to April 2012 and were randomly divided into experiment group and control group.Experiment group was treated by the repeat PKRBT for 4-6 weeks after the interval of the first resection,two groups were treated with adjuvant intravesical chemotherapy when finished resection.All of them were given a cystoscopy every three months and were followed up for 20 months,then we evaluated the tumor recurrence rates of the two groups.Results After 20 months of the following up in two groups,the recurrence rate of experiment group was 19.4％ and 41.9％ in control group,there was a significant reduction in experiment group compared with control group,the difference was statistically significant （P ＜ 0.05）.Conclusion The tumor recurrence rate can been reduced when the patients with high risk NMIBC accept the repeat PKRBT and adjuvant intravesical chemotherapy after resection,and we can obtain more accurate pathological staging by it.

关 键 词：经尿道等离子体双极电切术 膀胱灌注化疗 中高危非肌层浸润性膀胱癌 

分 类 号：R737.14[医药卫生—肿瘤]