胸腹水中Survivin、VEGF、端粒酶活性检测的临床价值  

Clinical value of detecting Survivin,VEGF and telomerase activity of pleural effusion and ascites

作　　者：李荣娟 

机构地区：[1]山东省青岛疗养院检验科,山东青岛266600

出　　处：《医学检验与临床》2014年第1期6-8,共3页Medical Laboratory Science and Clinics

摘　　要：目的：观察生存素（survivin）、血管内皮生长因子（VEGF）和端粒酶活性（TA）含量在鉴别诊断良恶性胸腹水性质的临床价值。方法：采用酶联免疫吸附试验（ELISA），对146例良恶性肿瘤患者胸腹水中Survivin、VEGF和TA进行了检测。结果：73例恶性胸腹水中Survivin、VEGF和TA指标分别为233．45±50．27ng／L、320．31±59．62μg／L．32．92±10．44μg／L，均分别显著高于73例良性胸腹水78．90±27．16ng／L、76．20±22．94μg／L、8．40±2．78斗g／L三者的含量（P均〈0．01）；Survivin、VEGF和TA在恶性胸腹水q-的诊断阳性率依次为72．6％、76．7％、75．3％，三项指标联各测定后阳性率捷高到86．3％。结论：Survivin、VEGF和TA测定对于良恶性胸腹水性质的鉴另，具有重要价值，将survivin、VEGF和TA联合检测，可显著提高阳性诊断率。Objective ： To investigate the clinical value in differentiating benign from malignant pleural effusion and ascites by detecting concentrations of Survivin, vascular endothelial growth factor（VEGF） and telomerase activity（TA）. Methods ： 146 patients with benign or malignant tumor were selected, concentrations of Survivin, VEGF and TA of pleura] effusion or ascites were detected by Enzyme linked immunosorbent assay（ELISA） method.Results ： Concentrations of Survivin, VEGF and TA of malignant effusions in 73 cases were 233.45 ± 50.27ng/L,320.31 ± 59.62μ g/L and 32.92 ± 10.44 μ g/L respectively, and they were significantly higher than those （78.90 ± 27.16ng/L,76.20 ± 22.94 μ g/L,8.40 ± 2.78 μ g/L）of benign effusions respectively（P 〈 0.01）;Positive rates in diagnosis of malignant effhsions by concentrations of Survivin, VEGF and TA were 72.6%, 76.7% and 75.3%, after detecting combined of three indicators ,the positive rate increased to 86.3%. Conclusions ： The concentrations of Survivin, VEGF and TA have high value for differentiating benign from malignant effusion, and joint detection of Survivin, VEGF and TA can significantly increase positive disinosis rate.

关 键 词：胸水 腹水 生存素 血管内皮生长因子 端粒酶活性 

分 类 号：R735.7[医药卫生—肿瘤]