抑郁症局部皮质电活动的脑磁图个体化分析  

Deficits of magnetoencephalography regional power in patients with major depressive disorder： an individual spectral analysis

作　　者：汤浩[1] 卢青[2] 李浩然[2] 韩莉[1] 罗国平[2] 姚志剑[1] 

机构地区：[1]南京医科大学附属脑科医院精神科,210029 [2]东南大学学习科学研究中心

出　　处：《中华精神科杂志》2014年第2期65-69,共5页Chinese Journal of Psychiatry

基　　金：国家自然科学基金（81371522,61372032）

摘　　要：目的 应用个体化分析方式探讨抑郁症静息脑磁频谱分布的特点,并初步评估静息脑磁能量异常与抑郁症严重程度之间的关系.方法 19例抑郁症患者（病例组）以及19名性别、年龄、受教育程度相匹配的健康对照（对照组）接受脑磁图静息态扫描,通过个体化频谱分析计算δ、θ、慢α1、慢α2、快α、β各频段在感兴趣皮质区的相对能量,基于双样本t检验获得组间差异;采用Spearman相关分析评估能量异常与抑郁症严重程度之间的关系.结果 病例组右额叶慢α2[病例组：（0.27±0.19）fT2,对照组：（0.51 ±0.37） fT2;t=-2.224,P=0.016]及快α[病例组：（0.42±0.39） fT2,对照组：（1.28±0.62）fT2;t=-1.856,P=0.036]、右颞θ[病例组：（1.13±0.42）fT2,对照组：（1.48±0.83） fT2;t =-1.785,P=0.041]频段能量显著低于对照组,左顶β[病例组：（4.35±2.64）fT2,对照组：（2.82±1.29） fT2;t =2.590,P=0.007]、右顶β[病例组：（4.45 ±2.48） fT2,对照组：（2.91±1.99） fT2;t2.670,P=0.006]、左枕β[病例组：（6.49±2.43）fT2,对照组：（5.22±2.78） fT2;t=1.769,P=0.043]、右枕慢α1[病例组：（2.03±1.06）fT2,对照组：（1.02±0.84） fT2;t=1.835,P=0.037]能量显著强于对照组;病例组右枕慢α1能量与HAMD17分值呈显著正相关（r=0.508,P=0.026）.结论 抑郁症能量异常的脑区和频段较为广泛,同时可能存在更复杂的α波活动模式,而头后部慢α1频段的能量水平值得考虑作为评估抑郁症严重程度的潜在指标.Objective To explore the discrepancies of individualized frequency and band power between major depressive disorder (MDD) and controls in resting state,and the association of abnormal spectral power with clinical severity of MDD.Methods Whole-head MEG recordings were collected in 19 patients with MDD and 19 non-depressed controls in eye-closed resting state.Individual spectral power of each subject was calculated based on the method of individually defined spectral bands and widths.Spearman correlation coefficient was used to examine the relation between the significant abnormal band power and the clinical indices of depression severity according to HAMD17 scores.Results The power of various frequency bands of patients was decreased as follows:the lower alpha2 [(0.27 ±0.19) fT2vs.(0.51 ±0.37) fT2;t=-2.224,P =0.016] and upper alpha band [(0.42±0.39) fT2vs.(1.28±0.62) fT2; t=-1.856,P =0.036] in the right frontal lobe,and the theta band in the right temporal lobe[(1.13 ±0.42) fT2vs.(1.48 ± 0.83) fT2 ; t =-1.785,P =0.041].The power was increased as follows:the beta frequency in the left parietal [(4.35 ± 2.64) fT2 vs.(2.82 ± 1.29) fT2 ; t =2.590,P =0.007],right parietal [(4.45 ± 2.48) fT2vs.(2.91±1.99) fT2; t =2.670,P=0.006]and left occipital lobe[(2.03 ±1.06) fT2vs.(1.02 ±0.84) fT2; t =1.835,P =0.037],and the lower alpha1 band in the right occipital lobe [(6.49 ± 2.43) fT2 vs.(5.22 ± 2.78) fT2 ; t =1.769,P =0.043].A positive correlation was observed between the right occipital lower alpha1 power and HAMD17 scores for depression (r =0.508,P =0.026).Conclusions MDD patients may have a broad disorganization of spectral power which be characterized with complex alpha activity patterns.The power of lower alpha1 of the right occipital lobe may be a potential indicator of depression severity.

关 键 词：抑郁症 脑磁图描记术 频谱分析 静息态 α峰频 

分 类 号：R749.4[医药卫生—神经病学与精神病学]