多巴胺受体1基因遗传多态性与精神分裂症病例-对照关联研究的meta分析  

The association between dopamine D1 receptor gene polymorphisms and schizophrenia：a meta-analysis

作　　者：潘雨晴[1] 姚军[1] 邢佳鑫[1] 王保捷[1] 

机构地区：[1]中国医科大学法医学院,沈阳110001

出　　处：《中华精神科杂志》2014年第2期79-83,共5页Chinese Journal of Psychiatry

摘　　要：目的 评价多巴胺受体1基因（DRD1）与精神分裂症发病风险的关系.方法 以病例-对照研究为基础,按照统一的检索策略在中英文数据库中（中国期刊全文数据库、万方数字化期刊全文数据库、维普中国科技期刊数据库、PubMed、Web of Science）检索相关文献,对文献进行筛选、评价后得到相关研究的结果数据,应用Stata10.0软件中的meta分析方法计算合并比值比（odds ratios,OR）及95％可信区间（confidence intervals,CI）,并进行敏感度分析和发表偏倚的估计.结果 共有10篇文献符合纳入标准,其中rs4532位点9篇,rs5326位点4篇.DRD1基因的rs4532位点与精神分裂症的发生不具有关联性（P＞0.05）,rs5326位点GA基因型与精神分裂症的发生具有关联性（P=0.001）,携带GA基因型者患精神分裂症的风险是携带GG基因型的1.38倍（GA vs GG：OR=1.38,95％ CI：1.14 ～ 1.68）.结论 DRD1基因的rs5326位点与精神分裂的发生具有关联性.Objective This study was carried out to examine the association between DRD1 gene polymorphism and the risk of schizophrenia. Method Relevant case-control studies were retrieved by Chinese and English database （CNKI, WANFANG, VIP, PubMed and Web of Science） and selected according to established inclusion criteria. The meta-analysis was performed using Stata version 10. 0. The strength of the association was measured by odd ratios （OR） with 95% confidence intervals （confidence intervals, C1）. Publication bias and sensitivity analysis were carried out. Results A total of 10 articles were identified and included in the recta-analysis, 9 for rs4532 and 4 for rs5326. No significant association was found between rs4532 locus and schizophrenia （P 〉 0. 05）. For rs5326 locus, the GA genotype was associated with schizophrenia （P = 0. 001 ） as a risk factor （ GAvs GG： OR = 1.38, 95% CI： 1. 14 - 1.68）. Conclusion DRD1 gene rs5326 locus may be associated with the occurrence of schizophrenia.

关 键 词：受体 多巴胺 精神分裂症 多态性 单核苷酸 META分析 

分 类 号：R749.3[医药卫生—神经病学与精神病学]