CD44v6、MUC1及VEGF在三阴性乳腺癌组织中的表达及其临床意义  

Expressions of CD44v6,MUC1 and VEGF in Triple-negative Breast Cancer and Their Significances

作　　者：孟迪[1] 冯晓燕[2] 进淑娟[1] 戴振华[2] 韩小伟[1] 郝晓鹏[1] 张贺秋[2] 黄焰[1] 

机构地区：[1]军事医学科学院附属医院,北京100071 [2]军事医学科学院基础医学研究所,北京100850

出　　处：《肿瘤学杂志》2014年第2期91-96,共6页Journal of Chinese Oncology

摘　　要：[目的]探讨CD44v6、MUC1及VEGF在三阴性乳腺癌中的生物学特征及其对预后评估的意义。[方法]采用免疫组织化学SP法检测CD44v6、MUC1及VEGF在104例三阴性乳腺癌、168例非三阴性乳腺癌中的表达。[结果]CD44v6及MUC1在三阴及非三阴性乳腺癌中的表达无明显差异,VEGF在非三阴性乳腺癌的表达明显高于三阴性乳腺癌(P<0.05)。在三阴性乳腺癌中,CD44v6、MUC1及VEGF表达与年龄、组织学分级、肿瘤大小、临床分期、淋巴结转移均无明显相关性;在非三阴性乳腺癌中,除CD44v6在无淋巴结转移组表达明显高于转移组(P<0.05)外,CD44v6、MUC1及VEGF表达与其他临床病理参数均未见明显相关性。CD44v6、MUC1及VEGF联合检测,阳性率明显增加。但不同组合中三阴性乳腺癌及非三阴性乳腺癌的表达仍无差别。[结论]未发现CD44v6、MUC1及VEGF在三阴性乳腺癌中存在表达优势,且与预后参数如临床分期、组织学分级、淋巴结转移情况无明显相关性,其预后价值有待进一步验证。[Purpose] To investigate the expressions of CD44v6,MUC1 and VEGF in triple-negative breast cancer （TNBC） and their relationship with prognosis. [ Methods I Expressions of CD44v6, MUC 1 and VEGF were determined by immunohistochemistry （IHC）. Their relationships with age,histologic grade, tumor size,lymphatic metastasis, clinical stage were analyzed. [ Results I Expressions of CD44v6 and MUC 1 showed no statistically significant difference between TNBC and NTNBC. The expression of VEGF was significantly higher in NTNBC than that in TNBC （P〈0.05）.No correlation was between the expression of CD44v6,MUC1 and VEGF with age,histologic grade,tumor size,lymphatic metastasis, clinical stage in TNBC;In NTNBC,except the significant correlation between CD44v6 expression and negative lymph node （P〈0.05）.No correlation was found between the expression of CD44v6, MUC1 and VEGF and the other related clinicopathological characteristics.The joint detection of CD44v6, MUC1 and VEGF enhanced the positive rate,but could not distinguish the TNBC and NTNBC. [Conclusionl CD44v6,MUC1 and VEGF don＇t show high expression in TNBC than those in NTNBC,in terms of no correlation between their expression and prognosis related factors such as histologic grade ,lymphatic metastasis, clinical stage.Their roles served as prognosis indicators in TNBC need further validation.

关 键 词：乳腺肿瘤 CD44V6 MUC1 VEGF 预后 

分 类 号：R737.9[医药卫生—肿瘤]