DMBT1在乳腺癌组织中的表达及临床意义  

Expression of DMBT1 in Breast Cancer Tissue and Its Clinical Significance

作　　者：王瑞海 崔大为[2] 翟宏芳[3] 

机构地区：[1]唐山市开平区医院,河北唐山063000 [2]唐山市工人医院,河北唐山063000 [3]唐山市人民医院,河北唐山063000

出　　处：《肿瘤学杂志》2014年第2期102-105,共4页Journal of Chinese Oncology

摘　　要：[目的]探讨脑恶性肿瘤缺失基因1(DMBT1)在乳腺癌组织中的表达及意义。[方法]采用免疫组织化学方法检测73例乳腺癌组织及距其癌组织边缘2cm以上镜下未见癌浸润的正常组织中DMBT1蛋白的表达情况。[结果]免疫组织化学结果表明,DMBT1蛋白在乳腺癌组织及正常乳腺组织中的表达阳性率分别为35.6%、70.9%,差异有统计学意义(P<0.05)。DMBT1蛋白表达与T分期、分化程度、淋巴结转移以及临床分期有关(P<0.05)。KaplanMeier生存分析提示,DMBT1表达阳性的乳腺癌患者5年总生存率明显高于表达阴性者,两者比较差异具有统计学意义(P<0.05)。[结论]乳腺癌组织中DMBT1蛋白表达降低,且与乳腺癌T分期、分化程度、淋巴结转移、临床分期及患者预后有关。[Purpose] To investigate the expression of deleted in malignant brain tumor 1 （DMBT1） in breast carcinoma tissues and its significance. [Methods] Immunohistochemistry was used to detect DMBT1 protein expression in 73 cases of breast cancer tissues and 31 cases of normal tissues. [Results] The level of DMBT1 protein expression was significantly lower in breast cancer tissues than that in normal tissues （P〈0.05）. The level of DMBT1 protein expression correlated to T stage,lymph node metastasis, clinic stage and histological grade（P〈0.05）. Loss of DMBT1 expression correlated significantly to poor overall survival by Kaplan-Meier analysis. [Conclusion] DMBT1 expression decreases in breast cancer tissues and correlates to T stage, lymph node metastasis,clinic stage,histological grade and overall survival,suggesting that DMBT1 may play an important role in breast cancer.

关 键 词：DMBT1 乳腺肿瘤 预后 肿瘤转移 

分 类 号：R737.9[医药卫生—肿瘤]