噻吩并嘧啶二酮类衍生物的合成方法研究  

A Method for Synthesis of Thienopyrimidines Derivatives

作　　者：茹婷婷[1] 丁晓岩 

机构地区：[1]吉林建筑大学,吉林长春130118 [2]通化市东昌区江东乡中心小学,吉林通化134000

出　　处：《辽宁化工》2014年第3期244-245,共2页Liaoning Chemical Industry

摘　　要：通过aza-Wittig反应得到了两个对称和不对称的四取代噻吩并双嘧啶二酮类化合物,并通过实验优化了该成环反应的反应条件。此方法具有反应条件温和,实验操作比较简便,所用原料价廉易得,反应所需时间短以及产率高等优点。Synthesis of novel thienopyrimidine derivatives and benzothienopyrimidine derivatives via aza-Witting reaction was studied. The condition for cyclization was optimized, biological activities of some compounds were also researched. The method has several advantages including mild reaction conditions, simple operation, inexpensive reagents and short reaction time.

关 键 词：噻吩并嘧啶酮类衍生物 AZA-WITTIG反应 生物活性 

分 类 号：O626[理学—有机化学]