pH-responsive mesoporous silica nanoparticles employed in controlled drug delivery systems for cancer treatment  

作　　者：Ke-Ni Yang Chun-Qiu Zhang Wei Wang Paul C.Wang Jian-Ping Zhou Xing-Jie Liang 

机构地区：[1]State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University [2]CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences [3]Laboratory of Molecular Imaging, Department of Radiology, Howard University

出　　处：《Cancer Biology & Medicine》2014年第1期34-43,共10页癌症生物学与医学（英文版）

基　　金：supported by the Chinese Natural Science Foundation Project (Grant No. 30970784 and 81171455);a National Distinguished Young Scholars Grant (Grant No. 31225009) from the National Natural Science Foundation of China;the National Key Basic Research Program of China (Grant No. 2009CB930200);the Chinese Academy of Sciences (CAS) ‘Hundred Talents Program’ (Grant No. 07165111ZX);the CAS Knowledge Innovation Program, and the State HighTech Development Plan (Grant No. 2012AA020804);the ‘Strategic Priority Research Program’ of the Chinese Academy of Sciences (Grant No. XDA09030301);NIH/NIMHD 8 G12 MD007597;USAMRMC W81XWH-10-1-0767 grants

摘　　要：In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles （MSNs） with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanopartides, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. These categories will be described in detail.In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles(MSNs) with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanoparticles, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. These categories will be described in detail.

关 键 词：Mesoporous silica nanoparticles PH-RESPONSIVE controlled drug release drug delivery systems antineoplastic protocols 

分 类 号：R730.5[医药卫生—肿瘤]