含二茂铁基吡唑啉的合成及抗真菌活性  

Synthesis and Antifungal Activity of Pyrazoline Containing Ferrocenyl

作　　者：赵军龙[1,2] 苟小锋[1,2] 刘栋[1,2] 王嫚[1,2] 花成文[1,2] 

机构地区：[1]合成与天然功能分子化学教育部重点实验室,陕西西安710069 [2]西北大学化学与材料科学学院,陕西西安710069

出　　处：《精细化工》2014年第4期534-538,共5页Fine Chemicals

摘　　要：以二茂铁为起始原料,合成了乙酰基二茂铁,再与醛反应,合成1-二茂铁基-3-(R1苯基)-2-丙烯酮,然后再与水合肼反应合成吡唑啉,最后通过与酰氯反应生成11个N-酰基-3-二茂铁基-5-芳基吡唑啉化合物。通过1HNMR、FTIR及ESI-HRMS进行了目标化合物结构的表征;将合成的吡唑啉化合物分别对4种植物真菌病(小麦赤霉病、马铃薯干腐病、烟草赤星病、西瓜枯萎病)进行了初步的抗植物真菌活性实验,测试结果显示,部分化合物具有良好的抗植物真菌活性。A series of pyrazoline derivatives were designed and synthesized from acetylferrocene, benzaldehyde, hydrazine hydrate and acyl chloride. The structures of the target compounds were confirmed by 1HNMR, FTIR and ESI-HRMS. Finally, the primary antimycotic activity of the title compounds against four types of plant mycosis （ GibberUa saubinetii, Pythium solani, Gibberlla nicotiancola, Fusarium oxysporium f. s.p. niveum） had been screened. The final results indicate that some of the compounds have a good plant anti-fungal activity.

关 键 词：二茂铁 吡唑啉 抑菌活性 精细化工中间体 

分 类 号：TQ455.4[化学工程—农药化工]