A new furostanol glycoside from Reineckia carnea  

吉祥草中一个新的呋甾皂苷（英文）

作　　者：胡艳维[1,2] 王璇[1,2] 谢可辉[2] 涂光忠[3] 袁丹[1] 付宏征[2] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]北京大学医学部天然药物及仿生药物国家重点实验室,北京100191 [3]北京微量化学研究所,北京100091

出　　处：《Journal of Chinese Pharmaceutical Sciences》2014年第3期177-181,共5页中国药学（英文版）

基　　金：National Natural Science Foundation of China(Gr ant No.81172943)

摘　　要：Phytochemical investigations of the aerial parts of Reineckia carnea, collected in Yunnan Province of China, were conducted to explore new chemical constituents. A series of chromatographic and spectroscopic procedures were utilized on the aqueous solution after partitioned with ethyl acetate, which resulted in the separation of a new furostanol-type glycoside and four known compounds. The structures of the isolated compounds were elucidated on the basis of spectroscopic techniques（1D and 2D NMR, IR, HRESIMS） as 26-O-β-D-glucopyranosyl-（25S）-5β-furost-20（22）-en-1α,3β,26-triol-1-O-α-L-arabinopyranosyl-（1→2）-[α-Lrhamnopyranos-yl]-3-O-α-L-rhamnopyranoside（1）,（1β,3β,16β,22S）-cholest-5-en-1,3,16,22-tetrol-1,16-di-（β-D-glucopyranoside）（2）, diosgenin（3）, β-sitosterol（4）, ecdysterone（5）.对云南产吉祥草的地上部分进行了植物化学研究。针对乙酸乙酯萃取后的水溶液,利用一系列色谱方法分离得到了一个新呋甾皂苷和四个已知化合物。通过1D NMR、2D NMR,IR和HRESI-MS的方法对分离得到化合物进行了结构鉴定,分别为26-O-β-D-glucopyranosyl-(25S)-5β-furost-20(22)-en-1α,3β,26-triol-1-O-α-L-arabinopyranosyl-(1→2)-[α-Lrhamnopyranosyl]-3-O-α-L-rhamnopyranoside(1),(1β,3β,16β,22S)-cholest-5-en-1,3,16,22-tetrol-1,16-di-(β-D-glucopyranoside)(2),diosgenin(3),β-sitosterol(4),ecdysterone(5)。

关 键 词：Reineckia carnea Steroidal glycosides STEROIDS Structural identification 

分 类 号：R284[医药卫生—中药学]