卡培他滨联合奥沙利铂治疗晚期结肠癌65例临床观察  

Clinical observation of capecitabine combined with oxaliplatin in the treatment of 65 patients with advanced colon cancer

作　　者：王静[1] 谷华伟 洪永贵[1] 

机构地区：[1]河南省安阳市肿瘤医院内一科,455000

出　　处：《中国实用医刊》2014年第9期34-36,共3页Chinese Journal of Practical Medicine

摘　　要：目的比较卡培他滨联合奥沙利铂与奥沙利铂单独治疗晚期结肠癌的疗效。方法将130例晚期结肠癌患者随机分为观察组和对照组，每组65例。观察组采取卡培他滨联合奥沙利铂治疗，对照组使用奥沙利铂单独治疗。观察两组治疗后的疗效、治疗前后卡式功能状态评分、生存时间、1．5年病死率和不良反应情况，以评价两种治疗方法的效果。结果观察组完全缓解、部分缓解、稳定、恶化患者分别有9、22、26和8例，治疗总有效率为47．69％，疾病控制率为87．69％，相比于对照组的29．23％和67．69％，差异有统计学意义（P〈0．05）。观察组生存时间明显长于对照组，1．5年病死率显著低于对照组（P〈0．05）。两组治疗前后KPS功能评分和不良反应发生率比较差异无统计学意义（P〉0．05）。结论相比于单独使用奥沙利铂，卡培他滨联合奥沙利铂治疗晚期结肠癌可以显著提升疗效．改善患者预后．值得在临床中推广使用。Objective To compare the effects of capecitabine combined with oxaliplatin and ox- aliplatin monotherapy on patients with advanced colon cancer. Methods One hundred and thirty cases of advanced colon cancer were randomly divided into observation group and control group, with 65 cases in each group. Patients in observation group were given capecitabine combined with oxaliplatin therapy, and patients in control group were given oxaliplatin alone. The efficacy, KPS function scores before and after treatment, survival time, 1.5 year mortality and adverse reactions were observed, in order to evalu- ate the effects of the two treatment methods. Results There were 9, 22, 26, 8 patients with complete remission （CR） , partial response （ PR）, stable （ SD ） , deterioration （ PD ） in the observation group, re- spectively. The total effective rate was 47.69%, disease control rate was 87.69 %, compared to the control group （29.23% and 67.69% ）, there were significant differences （P 〈 0.05 ）. The survival time was significantly longer than that in control group, 1.5 year mortality was significantly lower than that in control group （P 〈 0. 05 ）. There were no significant differences in KPS function scores before and after treatment and incidence of adverse reactions （ P 〉 0. 05 ）. Conclusions Compared with oxaliplatin a- lone, eapecitabine combined with oxaliplatin in the treatment of advanced colon cancer can significantly improve the efficacy and outcomes, it is worthy promoting in clinics.

关 键 词：化疗 肿瘤 结肠癌 奥沙利铂 卡培他滨 

分 类 号：R735.35[医药卫生—肿瘤]