血清microRNA检测在肝细胞癌诊断中的研究进展  

Research progress in serum microRNA detection for diagnosis of hepatocellular carcinoma

作　　者：渠亚超 闾军[1] 

机构地区：[1]首都医科大学附属北京佑安医院肝病与肿瘤生物治疗科,北京100069

出　　处：《临床肝胆病杂志》2014年第3期228-232,共5页Journal of Clinical Hepatology

基　　金：北京市卫生系统高层次卫生技术人才培养项目资助(2011-J.L.);首都医学发展科研基金(2009-3156)

摘　　要：随着肝细胞癌(HCC)患病率和病死率的逐渐上升,寻找精确、简便易行而无创的早期诊断标志物越来越重要。小分子RNA(microRNAs,miRNAs)是一类内源性非编码的小RNA,广泛存在于动物、植物和病毒中,并且在血清和组织中均稳定表达。介绍了miRNAs作为促癌基因和抑癌基因在肿瘤发生和发展中的作用,总结了多种血清miRNAs在肝细胞癌中的异常表达情况。分析表明可以利用这些稳定表达的miRNAs作为早期诊断肿瘤的无创性标志物。With the rising incidence and mortality of HCC, accurate, simple, and non - invasive biomarkers are increasingly needed for the early diagnosis of this disease. MicroRNAs （miRNAs） are a class of endogenous non - coding small RNAs, which have been widely found in animals, plants, and viruses and are stably expressed in both sera and tissues. The roles of mil^NAs as oncogenes or tumor suppressor genes in the development and progression of HCC are described, and the aberrant expression of serum miRNAs in HCC is summarized. Analyses showed that these stably expressed miRNAs can be used as non - invasive biomarkers for early diagnosis of HCC.

关 键 词：癌 肝细胞 微RNAS 早期诊断 综述 

分 类 号：R735.7[医药卫生—肿瘤]