早期肠内营养对结直肠癌病人术后恢复的影响  

Effect of early enteral nutrition on clinical outcomes after colorectal cancer surgery

作　　者：韩芳[1] 李晓迪[1] 宗轶 刘晔[1] 程梦婕[1] 

机构地区：[1]广州军区武汉总医院营养科,湖北武汉430070 [2]深圳市宝安区福永人民医院肛肠科,广东深圳518103

出　　处：《肠外与肠内营养》2014年第2期80-82,共3页Parenteral & Enteral Nutrition

摘　　要：目的:观察结直肠癌根治术后早期肠内营养(EEN)的临床疗效及评价其安全性和可行性。方法:回顾性分析75例结直肠癌病人的临床资料,其中EEN组39例,全肠外营养(TPN)组36例。EEN组病人术后24 h开始经鼻肠管输注或口服EN制剂,TPN组经中心静脉进行营养支持。两组病人的营养支持均为等热量和等氮量,观察两组病人营养状况变化、术后并发症发生情况、肠功能恢复情况、住院时间和营养费用等。结果:术后第8天,EEN组病人总淋巴细胞计数明显高于TPN组(P<0.05),其他营养指标变化无显著性差异(P>0.05);EEN组肠功能恢复较TPN组病人快,营养相关费用和住院费用较TPN组低(P<0.05);EEN组术后并发症的发生率虽低于TPN组,但无显著性差异(P>0.05)。结论:结直肠癌病人不仅可安全耐受术后EEN,而且还能提高免疫功能,促进胃肠功能恢复,降低术后并发症。Objective ： To evaluate the safety and clinical effect of postoperative early enteral nu- trition （EEN） after radical treatment of patients with colorectal cancer. Methods ： Seventy-five patients with colorectal cancer were analyzed retrospectively and divided into two groups, EEN group （ n = 39 ） and TPN group （ n = 36）. Two groups were fed with equal quantity of nitrogen and calorie. EEN started 24 hours after surgery. EEN was infused through a nasojejunal tube or taken orally. TPN was provided via peripheral or central vein. Some parameters （nutritional status, postoperative complications, recovery of intestinal motility, hospital stay and cost of nutrition support） were measured and compared them. Results： The total lymphocyte count was significantly different between the two groups on 8th postopera- tive day（P 〈0.05 ）, and there were no significant differences between EEN and TPN support in other nutritional indices （P 〉 0.05 ）. The recovery of intestinal motility was shorter in the EEN group （ P 〈 0.05 ）. Conclusion： The early enteral nutrition is not only well tolerated but also affected the postop- erative outcomes positively.

关 键 词：早期肠内营养 全肠外营养 结直肠癌 

分 类 号：R735.3[医药卫生—肿瘤] R459.3[医药卫生—临床医学]