唾液腺腺样囊性癌474例临床病理分析  

Adenoid cystic carcinoma of salivary gland:a clinicopathological study of 474 consecutive cases

作　　者：张春叶[1] 邓旭霞[2] 田臻[1] 王丽珍[1] 胡宇华[1] 李蕾[1] 李江[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔病理科,上海市口腔医学重点实验室,上海200011 [2]中国石油中心医院口腔科,河北廊坊065300

出　　处：《中国口腔颌面外科杂志》2014年第2期126-130,共5页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(81302360);教育部博士点基金(20120073110085)~~

摘　　要：目的：分析474例唾液腺腺样囊性癌（adenoid cystic earcinoma，ACCl的临床病理特征。方法：回顾分析上海交通大学医学院附属第九人民医院口腔病理科诊断为原发性ACC的474例临床病理资料。采用SPSSl8．0软件包对数据进行统计学处理。结果：474例ACC中，男女之比为1．03：1（240：234）；发病年龄11～83岁，平均年龄52岁；腮腺和腭部分别是大小唾液腺中最常见的部位；病程1个月～37a不等，平均21个月：64％的患者出现不同程度的症状：72％的患者就诊时TNM分期为Ⅱ期和Ⅲ期；组织学上．76％的患者表现为筛状／管状型。组织学类型为实体型者较筛状／管状型者更易发生颈淋巴结转移（P=0．016）。结论：ACC多见于中老年人，腮腺和腭部最常见。临床上多伴有不同程度的症状，组织学表现以筛状／管状型多见，实体型者更易发生颈淋巴结转移。PURPOSE： To investigate the clinicopathological features of salivary adenoid cystic carcinoma （ACC） in 474 Chinese patients. METHODS： The clinical and pathological characteristics of 474 primary salivary ACC diagnosed in Department of Oral Pathology, Ninth People＇s Hospital, Shanghai Jiao Tong University School of Medicine were analyzed. SPSS18.0 software package was used for statistical analysis. RESULTS： Of the 474 ACC cases, the male-to-female ratio was 1.03：1 （240 to 234）; the mean age was 52 years （from 11 to 83）; the parotid and the palate were the most common locations of major and minor salivary gland respectively; the mean clinical course was 21 months （from 1 month to 37 years）; 64% （301/474） patients had clinical symptom; 72%（343/474） patients were TNM stage ]] and m; 76%（360/474） patients had cribriform and tubular histological subtype. Tumor with solid pattern was associated with higher cervical lymph node metastasis （P=0.016）. CONCLUSIONS： In Chinese population, ACC is more common in elder people and frequently involves the parotid gland and the palate. Most patients have clinical symptoms and histologically, cribriform and tubular types are more common. Patients with solid pattern have higher possibility to develop cervical lymph node metastasis than those with cribriform and tubular patterns. Supported by National Natural Science Foundation of China （81302360） and Research Fund for Doctoral Program of Ministry of Education of China（20120073110085）.

关 键 词：唾液腺 腺样囊性癌 临床病理分析 

分 类 号：R739.87[医药卫生—肿瘤]