肿瘤体积对食管癌患者生存期的影响  

Influence of tumor volume on survival of the patients with esophageal cancer

作　　者：郭明[1,2,3] 黄佳[1,2] 袁果 李吉林[5] 董金城 焦新英[5] 郭金生 魏锦昌 常扶保 李燕 王立东 

机构地区：[1]郑州大学第一附属医院河南省食管癌重点开放实验室 [2]郑州大学基础医学院,河南郑州450052 [3]河南省安阳市妇幼保健院,河南安阳455000 [4]新乡医学院,河南新乡453003 [5]林州食管癌医院,河南林州456592 [6]林州中心医院,河南林州456592

出　　处：《河南大学学报（医学版）》2014年第1期1-5,共5页Journal of Henan University:Medical Science

基　　金：国家科技部863重大项目(2012AA02A209)

摘　　要：目的探讨肿瘤体积对食管癌患者生存期的影响,加深对食管癌关键预后影响因素的了解。方法通过入户或电话问卷调查及生存随访,采用卡方检验、Kaplan-Meier生存曲线和Log Rank检验及COX生存分析模型,分析肿瘤体积≤6cm^3,6-18cm^3和≥18cm^3时对食管癌患者的生存期的影响。结果成功随访5 723例（95.8%）,其中男性3 666例,女性2 057例。随着肿瘤体积的增大患者生存期渐差（P=1.53E-13）。女性体积≤6cm^3患者明显多于男性,而体积≥18cm^3的患者明显少于男性（P〈0.05）,女性患者生存期显著优于男性患者（P=4.24E-8）。值得指出的是,青年组（≤50）体积≤6cm3的患者少于中老年组,而体积≥18cm3的患者明显多于中老年组（P〈0.05）,但青年患者生存期优于中老年患者（P=1.74E-9）。淋巴结转移阳性组肿瘤体积≤6cm^3患者少于淋巴结转移阴性组（P〈0.05）,生存期明显差于淋巴结转移阴性组（P=1.42E-59）。随着浸润程度的加深,肿瘤体积增大（P=4.58E-23）,患者生存期渐差（P=6.92E-16）。COX多因素生存分析模型提示,肿瘤体积是影响食管癌患者生存期的独立因素（P=0.005）。结论随着肿瘤体积的增大患者生存期渐差,肿瘤体积是影响食管癌患者生存期的独立因素。Objective The present study aimed to investigate the influence of tumor volume on the survival of patients with esophageal cancer, to further shed light on the key prognostic factors for esophageal cancer. Methods The questionnaire, home interview and / or telephone were performed for survival follow-up on esophageal cancer patients. The Chi-square test, Kaplan-Meier survival analysis, Log rank test and multivariate Cox regression model were applied to assess the survival for the tumor volume ≤6 cm^3, 6-18 cm^3 and ≥18 cm^3 esophageal cancer patients. Results 5723 cases （95.8%） were successful followed, including 3,666 males and 2,057 females. With the tumor volume increased, survival time significantly decreased in patients with EC（ P 〈0.05）. The rate of tumors volume of 46 cm3 in female patients was significantly higher than in male, and volume ~ 18 cm3 of female patients was significantly lower than in male （ P 〈0.05）. The survival time in female patients was significantly higher than in male （ P =4.24E-8）. It was noteworthy that, the rate of volume≤6 cm3of younger patients （〈50 years） was significantly lower than in elderly patients （≥50 years）, but volume ≥18 cm^3 of younger patients was significantly higher than in elderly patients （ P 〈0.05）. The survival time in younger patients was significantly higher in elderly patients （P = 1.74E-9）. The rate of volume 46 cm^3 of lymph node metastasis（LNM） positive patients was significantly higher than in lymph node metastasis negative patients（ P 〈0.05）. The survival time in LNM positive patients was significantly lower in LNM negative patients （ P = 1.42E-59）. With the invasion deepening, the tumor volume increased （ P = 4.58E-23）, and survival time significantly decreased （ P = 6.92E-16）. Cox regression analysis showed that, the volume tumor was one of the independent factors for esophageal cancer survival （P = 0. 005）. Conclusion With the volume increased, survival time significantly decr

关 键 词：食管癌 生存期 肿瘤体积 

分 类 号：R735.1[医药卫生—肿瘤]