滁菊水提物对肥胖症及血脂异常的预防作用  

Prevention of Aqueous Extract from Chrysanthemum Morifolium of ChuJu Against High-Fat Diet Induced Obesity and Dyslipidemia

作　　者：董克江[1] 刘均涛[1] 陈岩[1] 姚克非[1] 汤雷[1] 史亚东 陈容前[1] 

机构地区：[1]滁州城市职业学院,安徽滁州239000 [2]安徽菊泰滁菊草本科技有限公司,安徽滁州239000

出　　处：《食品研究与开发》2014年第4期101-104,共4页Food Research and Development

基　　金：安徽高校省级自然科学研究项目(NO.KJ2013Z241)

摘　　要：观察滁菊水提物对高脂饮食诱导的肥胖症及脂代谢异常的影响。采用高脂饲料饲喂小鼠8周诱导动物肥胖模型,然后观察滁菊水提物及VitE干预对小鼠增重、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDLC)、高密度脂蛋白(HDL-C)水平的影响。滁菊水提物干预能显著减轻高脂饮食诱导的增重效应、抑制血清TC、TG、LDL-C水平的升高,而对HDL-C水平影响不大;与滁菊的抑制效应类似,抗氧化剂VitE干预也可显著抑制高脂饲料组小鼠的增重及血清TC、TG、LDL-C水平的增加,而对HDL-C水平无影响。滁菊水提物能有效预防高脂饮食诱导的肥胖症、高脂血症,其作用机理可能与其抗氧化活性有关。To observe the effects of aqueous extract from chrysanthemum morifolium of ChuJu on obesity and dyslipidemia induced by high-fat diet. Using high-fat feed to establish animal model of obesity in mouse for 8 weeks. Then to determine the influence on body weight gain, serum levels of TC, TG , LDL-C, HDL-C with intervention of aqueous extract from chuju or administration of Vitamin E. Chuju aqueous extract significantly attenuated high-fat diet induced body weight gain and inhibited the increase of serum TC, TG , LDL-C levels caused by high-fat diet , while without affecting HDL-C level. Treatment of antioxidant vitamin E exhibited similar inhibitory effects to that of Chuju aqueous extract, which significantly decreased body weight gain, serum TC, TG and LDL-C levels and had no effect on HDL-C level. Intake of Chuju aqueous extract can effectively prevents high-diet induced obesity or dyslipidemia, which may be associated with its antioxidant effects.

关 键 词：滁菊 高脂饮食 肥胖症 血脂异常 预防作用 

分 类 号：R259[医药卫生—中西医结合]