吲哚参与的不对称Michael加成反应研究进展  

The Progress of Asymmetric Michael Addition Reaction of Indoles

作　　者：郭丰敏[1] 刘雄伟[1] 潘博文[1] 石洋[1] 刘雄利[1] 周英[1] 

机构地区：[1]贵州大学药学院,贵州省中药民族药创制工程中心,贵州贵阳550025

出　　处：《山地农业生物学报》2014年第1期81-86,共6页Journal of Mountain Agriculture and Biology

基　　金：贵州大学引进人才科研项目[贵大人基合字(2013)013号];教育部"新世纪人才支持计划"[教技函(2011)95号];贵州省优秀青年科技人才培养对象专项[黔科合人字2011(34)号]

摘　　要：吲哚骨架作为一种重要的官能团一直是天然产物化学和药物实体领域里的研究热点,并且近年来研究热度持续升温。由于其存在的抗氧化、抗菌和杀虫功效等生物学作用,吲哚取代物的制备受到广泛关注。催化下的吲哚与α,β-不饱和酮类,醛类,酯类等的不对称Michael加成反应是一类强有力的碳-碳键形成反应,这类反应在现实合成中有很多应用。很多吲哚参与的且针对不同受体的不对称Michael加成反应得到很大发展。本文总结了这一反应近几年来的研究进展,特别是对在不同催化剂催化下的反应受体进行了分类和总结。As an important functional group, the indole skeleton has been intensively eneerned in natural product chemistry and therapeutic agents. Recently, high attention had been paid in the preparation of substi- tuted indoles due to their various biological activities including antioxidant, antibacterial, and insecticidal be- havior. The catalyzed asymmetric Michael addition reaction of indoles with a, [3 - unsaturated ketones, alde- hydes, esters etc, is an powerful carbon - carbon bond forming process, and has many applications in chemi- cal synthesis. Highly efficient and enantio - selective catalysts have been developed in those asymmetric Mi- chael addition reactions, where different receptors have different substituted groups under different condi- tions. This review summarizes the recent progress in this area, especially the application of different catalysts in this reaction with different receptors.

关 键 词：MICHAEL加成 不对称催化 吲哚骨架 

分 类 号：O643.32[理学—物理化学]