胸部肿瘤调强放射治疗与常规放射治疗DVH参数比较及对心电图的影响  

Comparison of dose volume histogram parameters and dynamic electrocardiogram changes between intensity modulated radiation therapy and conventional radiotherapy for the thoracic tumor

作　　者：杨苏萍[1] 覃晓波[1] 蒿艳蓉[2] 张琴[1] 陈甲信[2] 莫晓云[3] 肖和卫[3] 

机构地区：[1]广西壮族自治区人民医院心电诊断科,南宁530021 [2]广西壮族自治区人民医院肿瘤科,南宁530021 [3]广西壮族自治区人民医院科研部,南宁530021

出　　处：《中国临床新医学》2014年第3期188-190,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西自然科学基金资助项目(编号:桂科自0832207);广西卫生厅重点科研课题(编号:桂卫重2012103);南宁市青秀区科学研究与技术开发课题(编号:2012S04)

摘　　要：目的比较胸部肿瘤调强放射治疗(IMRT)与常规放射治疗(CRT)剂量-体积直方图(DVH)参数及动态心电图(DCG)的改变情况。方法选择72例胸部肿瘤患者,根据治疗方案分为IMRT组和CRT组,每组36例,分别于治疗前、中、后进行24 h DCG监测,分析两组DVH参数及DCG改变情况。结果 IMRT组心脏V30、V40、V50均明显低于CRT组,差异有统计学意义(P<0.01),IMRT组及CRT组治疗前、中、后DCG异常发生率比较,差异有统计学意义(P<0.01),治疗中、后IMRT组DCG异常发生率均低于CRT组,差异有统计学意义(P<0.05)。结论两种治疗方法均可引起DCG改变,但在相同剂量照射时,IMRT组心脏受照体积减少,对DCG影响更小。Objective To compare the dose volume histogram （ DVH） parameters and dynamic electrocardio-gram（ DCG） changes between intensity modulated radiotherapy （ IMRT） and conventional radiotherapy （ CRT） for the thoracic tumor.Methods The patients with thoracic tumors were divided into IMRT group and CRT group ,with 36 cases in every group , two groups were tested with 24-hour DCG before , during and after treatment to compare DVH parameters and DCG changed .Results Heart V30-V50 in IMRT group were significantly lower than that in the CRT group, with statistical significance （ P〈0.01 ） , the abnormity incidence rates of DCG was statistically significant be-tween IMRT group and CRT group（before, during and after treatment）（P〈0.01）, the abnormity incidence rates of DCG were lower in IMRT group than that of CRT group during and after treatment , with statistical significance （ P〈0.05 ） .Conclusion Both treatments can cause DCG change , but at the same dose IMRT group has smaller heart ir-radiation volume and lighter change of DCG .

关 键 词：胸部肿瘤 调强放射治疗 常规放射治疗 DVH图 动态心电图 

分 类 号：R730[医药卫生—肿瘤] R540.41[医药卫生—临床医学]