不同降糖药物对2型糖尿病患者机体水溶性维生素水平的影响  

The effects of different commonly used antidiabetic drugs on water-soluble vitamins levels in patients with type 2 diabetes mellitus

作　　者：潘瑞蓉[1] 俞淑琴 孙文君[1] 王济芳[1] 钱唯韵[1] 庄若[1] 胡越[1] 高毅娜[1] 王宏星[2] 袁国跃[1] 王东[1] 

机构地区：[1]江苏大学附属医院内分泌科,镇江212001 [2]无锡市第三人民医院临床营养科

出　　处：《中国糖尿病杂志》2014年第4期340-343,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81370965);江苏省卫生厅面上项目(H2012047);镇江市社会发展项目(SH2012027;SH2013035);江苏大学临床医学科技发展基金(JLY20120175;JLY20120150)

摘　　要：目的比较3种口服降糖药(OAD)对T2DM患者机体水溶性维生素水平的影响。方法将80例T2DM住院患者分为4组,每组20例,于住院前及住院第5天检测FPG、2hPG,血清及尿VB1、VB6、VB12、VC和叶酸水平。结果各组FPG治疗后较治疗前下降(P<0.05)。各组间FPG变化值比较差异有统计学意义(P<0.05)。各组2hPG治疗后较治疗前下降(P<0.05)。各组间2hPG变化值比较差异有统计学意义(P<0.05)。A、C、D组血清VB1、VB6、VB12、VC和叶酸水平治疗后较治疗前降低(P<0.05),B组治疗前后比较差异无统计学意义,各组间变化值比较差异无统计学意义。各组尿VB1、VB6、VB12、VC和叶酸水平治疗前后比较差异有统计学意义(P<0.05),各组间变化值比较差异无统计学意义。结论 OAD治疗T2DM时应注意二甲双胍和阿卡波糖对水溶性维生素的影响。Objective To compare the changes of serum water-soluble vitamins in patients with T2DM among three commonly used antidiabetic drugs.Methods The hospitalized T2DM patients meeting the study conditions were divided into groups A （metformin）,B （glimepiride）,C （acarbose） and D （control group,matching any hypoglycemic drugs）,twenty cases in each group.No significant differences in blood sugar,complications and associated symptoms were found.Hospital diabetic diet was unifiedly arranged by clinical nutrition department.The diets in four groups have no significant difference.VB1,VB6,VB12,VC and folic acid in both serum and urine were examined before and five days after hospitalization.Results FPG is lower in four groups after treatment than before treatment （P〈0.05）.There were statistically significant differences in changes of FPG among groups （P〈0.05）.2 hPG is lower in four groups after treatment than before treatment （P〈0.05）.There were statistically significant differences in changes of 2 hPG among groups （P〈0.05）.The levels of serum VB1,VB6,VB12,VC and folic acid were lower after treatment than before treatment in groups A,C and D （P〈0.05） except for group B.The levels of serum VB1,VB6,VB12,VC and folic acid showed no significant differences between four groups.Urinary levels of VB1,VB6,VB12,VC and folic acid showed statistically significant differences in pre-versus post-treatment in four groups （P〈0.05）.The levels of urinary VB1,VB6,VB12,VC and folic acid showed no significant differences between four groups.Conclusion It should be noted that the using of acarbose and metformin may disturb the serum level of water-soluble vitamins.

关 键 词：糖尿病 2型 二甲双胍 格列美脲 阿卡波糖 水溶性维生素 

分 类 号：R587.1[医药卫生—内分泌]