动物细胞的简单单细胞模型  

SIMPLE SINGLE CELL MODEL OF ANIMAL CELLS

作　　者：高红亮[1] 丛威[1] 吕秀菊[1] 欧阳藩[1] 

机构地区：[1]中国科学院化工冶金研究所生化工程国家重点实验室,北京100080

出　　处：《化工学报》2001年第2期179-183,共5页CIESC Journal

基　　金：国家自然科学基金资助项目!(No .2 96 0 6 0 11)

摘　　要：An individual cell is a chemical reactor with thousands of reactions operated under a highly sophisticated control system,and it is a self-regulated reactor that can alter its biosynthetic machinery to meet its demands in a changing environment.A simple mathematical model for the growth of a single cell of hybridoma is presented in this work in which the cell is divided into structural and genetic compartments.This model can describe the changes in cell component,cell shape,cell size,substrate uptake, byproduct release and other temporal events during the cell division cycle.Some model parameters were regressed with experimental gross data of hybridoma in continuous culture,and specific uptake rate of glucose and glutamine of hybridoma in continuous culture were predicted.The predicted values were in good agreement with experimental data.The average relative deviation is 13.8%.An individual cell is a chemical reactor with thousands of reactions operated under a highly sophisticated control system,and it is a self-regulated reactor that can alter its biosynthetic machinery to meet its demands in a changing environment.A simple mathematical model for the growth of a single cell of hybridoma is presented in this work in which the cell is divided into structural and genetic compartments.This model can describe the changes in cell component,cell shape,cell size,substrate uptake, byproduct release and other temporal events during the cell division cycle.Some model parameters were regressed with experimental gross data of hybridoma in continuous culture,and specific uptake rate of glucose and glutamine of hybridoma in continuous culture were predicted.The predicted values were in good agreement with experimental data.The average relative deviation is 13.8%.

关 键 词：单细胞模型 动物细胞 细胞周期 细胞培养 

分 类 号：Q952[生物学—动物学]