含莫西沙星的补救方案对根除Hp的疗效分析  

Efficacy analysis of patients failed for eradication of helicobacter pylori remedial treatment with moxifloxacin triple therapy

作　　者：丁平[1] 王选举[1] 辛毅[1] 

机构地区：[1]安徽省宿州市立医院消化内科,234000

出　　处：《中华全科医学》2014年第5期739-740,757,共3页Chinese Journal of General Practice

摘　　要：目的观察含莫西沙星的三联疗法对幽门螺旋杆菌(Hp)根除失败患者的补救治疗效果及根除率。方法入选者为经14C-呼气试验证实为Hp阳性患者127例,至少行幽门螺旋杆菌根除治疗1次以上,所有患者随机分成2组,莫西沙星三联组64例给予含莫西沙星的三联疗法(莫西沙星+阿莫西林+雷贝拉唑)14 d;标准三联组63例给予标准三联疗法(克拉霉素+阿莫西林+雷贝拉唑)14 d。2组治疗结束后,停药1个月后复查14C-呼气试验,比较2组患者根除幽门螺旋杆菌的疗效及根除率。结果莫西沙星三联组Hp根除率93.8%(60/64),标准三联组Hp根除率74.6%(47/63),2组Hp根除率比较,差异有统计学意义(P<0.05),2组均无严重的副反应。结论对幽门螺旋杆菌根除失败患者,给予含莫西沙星的三联疗法比标准三联疗法有更好的治疗效果。Objective To evaluate the effect of remedial treatment with moxifloxacin triple therapy as remedial treatment of eradication of H. pylori infection. Methods A total of 127 patients with HP infection （ 14 C-urea breath test positive） failing in previous treatment one or more were enrolled and divided into 2 groups. The moxifloxaein based group was sim- ultaneously treated with amoxicillin and rabeprazole（ moxifloxacin 0.4 g po qd ＋ amoxicillin 0.5 g po bid ＋ rabeprazole 10 mg po bid, 14 d） ;the control group was treated with clarithromycin, amoxicillin and rabeprazole（ clarithromycin 0.5 g po bid ＋ amoxicillin O. 5 g po bid ＋ rabeprazolel0 mg po bid, 14 d）. The eradication rate of Hp was evaluated by 14C-urea breath test 4 weeks after the treatment. Results The Hp eradication rates of the moxifloxacin based group was 93.8% while that of the other group was 74.6% （ P 〈 0.05 ）. The difference of eradication rate was significant. No significant ad- verse reaction was observed. Conclusion The moxifloxacin based triple therapy was considered as one of effective thera- py options for the patients who failing in previous treatment.

关 键 词：三联疗法 幽门螺旋杆菌 补救治疗 

分 类 号：R573.3[医药卫生—消化系统] R516[医药卫生—内科学]