Incorporation of Bromelain into Dermatological Bases： Accelerated Stability Studies  

作　　者：Iara Rocha Antunes Pereira Bresolin Igor Tadeu Lazzarotto Bresohn Priscila Gava Mazzola Elias Basile Tambourgi 

机构地区：[1]School of Chemical Engineering, University of Campinas (Unicamp), Campinas 13083-970, Brazil [2]Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of S6o Paulo (Unifesp), Diadema09972-270, Brazil [3]Faculty of Medical Sciences, University of Campinas (Unicamp), Campinas 13083-881, Brazil

出　　处：《Journal of Chemistry and Chemical Engineering》2014年第3期270-277,共8页化学与化工（英文版）

摘　　要：This work aimed the incorporation of the enzyme bromelain from pineapple peel into dermatological bases for potential therapeutic application. The enzyme was incorporated into Lanette cream and lotion, as well as Carbopol gel and Chemyunion cream and lotion, at a concentration of 0.5% （w/w）. These bases were subjected to centrifugation test and accelerated stability test during 90 days at 25 ℃（with and without sunlight）, 37 ℃ and 4 ℃, in order to evaluate bromelain stability in dermatological bases. Total protein content and enzymatic activity were measured. The bases were stable as its organoleptic characteristics （appearance, color, smell and sensitivity to touch） only when kept at 4 ℃ with activity remaining 95.5%, 84,9%. 77.7%, 73.8% and 72.3%, alter 90 days of testing in Carbopol gel, Lanette and Chemyunion cream, and Lanette and Chemyunion lotion, respectively. Based on the results, it was possible to incorporate bromelain into dermatological bases, and the activity was well preserved when these bases were kept in refrigerator at 4 ℃.

关 键 词：Emulsions STABILITY BROMELAIN therapeutic applications enzymatic activity. 

分 类 号：TS201.25[轻工技术与工程—食品科学] V263.3[轻工技术与工程—食品科学与工程]