TP方案诱导化疗联合放疗治疗晚期鼻咽癌的近期疗效评价  

Short-term Effectiveness Evaluation of TP Induction Chemotherapy Followed by Radiotherapy for Local Advanced Nasopharyngeal Carcinoma

作　　者：叶旭[1] 吴湘伟[1] 刘雯[1] 韩亚骞[1] 陈艳平[1] 

机构地区：[1]中南大学湘雅医学院附属肿瘤医院放疗科,湖南长沙410003

出　　处：《肿瘤药学》2014年第2期131-134,共4页Anti-Tumor Pharmacy

摘　　要：目的探讨TP方案诱导化疗联合放疗治疗晚期鼻咽癌的疗效。方法以应用TP方案诱导化疗联合放疗治疗晚期鼻咽癌疼痛的55例患者作为联合组,以单纯应用放疗的53例晚期鼻咽癌疼痛患者作为对照组,观察两组患者鼻咽部病灶、颈部淋巴结转移及疼痛缓解情况。结果联合组患者鼻咽部病灶、颈部淋巴结转移改善情况及疼痛缓解效果均显著优于对照组,差异有统计学意义(P<0.05)。结论 TP方案诱导化疗联合放疗对局部晚期鼻咽癌患者的近期疗效明显优于单纯放疗,可于临床进一步应用。Objective To explore the effectiveness of TP induction chemotherapy followed by radiotherapy for patients of local advanced nasopharyngeal carcinoma. Methods A total of 108 cases of local advanced nasopharyngeal carcinoma were in-cluded in this study. Fifty-five cases were treated with TP induction chemotherapy followed by radiotherapy as the union group, whereas other fifty-three cases were treated merely with radiotherapy as control group. Nasopharyngeal lesions, neck lymph node metastasis and pain relief were observed and compared between two groups. Results The nasopharyngeal lesions, metas-tasizing neck lymph nodes and cancer pain were all relieved in different degrees in the union group and the effectiveness were superior to that of control group. Differences had statistical significance between two groups （P〈0.05）. Conclusion TP induction chemotherapy followed by radiotherapy has better short-term effectiveness than simple radiotherapy. It can effectively relieve pain of patients and could be further applied in clinic.

关 键 词：TP方案 化疗 放射 晚期鼻咽癌 

分 类 号：R739.6[医药卫生—肿瘤]