多西紫杉醇对鼻咽癌放疗增敏作用的临床观察  

Clinical Observation on the Sensitization Effects of Docetaxel on the Radiotherapy of Nasopharyngeal Carcinoma

作　　者：温本[1] 杨志华[1] 颜劲[1] 郑文滔 

机构地区：[1]湛江中心人民医院,广东湛江524037

出　　处：《肿瘤药学》2014年第2期135-138,共4页Anti-Tumor Pharmacy

摘　　要：目的研究多西紫杉醇在鼻咽癌放疗过程中的增敏作用及不良反应。方法将60例经病理确诊为鼻咽癌的患者随机分成实验组和对照组,每组30例。对照组行单纯放疗,实验组在放疗同时给予静滴多西紫杉醇40mg,1次/周,治疗1个月后比较两组的治疗效果及不良反应。结果治疗后,实验组的总有效率为83.33%,对照组的总有效率为53.33%,差异有统计学意义(P<0.05);两组间不良反应如白细胞下降、口干咽痛、皮肤反应、恶心、纳差的发生率比较,差异无统计学意义(P>0.05)。结论多西紫杉醇联合放疗治疗鼻咽癌,疗效明显优于单纯放疗,且不增加不良反应,值得在临床推广应用和进一步研究。Objective To study the sensitization effect and safety of Docetaxel on the radiotherapy of nasopharyngeal carci-noma. Methods Sixty cases of nasopharyngeal carcinoma patients confirmed by pathological diagnosis were randomly divided into the experimental group and control group, 30 cases in each group. The control group adopted single radiotherapy, while the experimental group was added with static drops of docetaxel 40 mg, 1 time per week. The therapeutic effect and adverse reac-tions were observed and compared between two groups after 1-month treatment. Results The total effective rate of experimental group and control group were respectively 83.33%and 53.33%, with statistically significant difference （P〈0.05）.There were no significant differences in the incidence rate of adverse reactions such as leukopenia, pharyngalgia, cutaneous reaction, nausea and vomitting between two groups （P〉0.05）. Conclusion Docetaxel combined with radiotherapy was more effective than single radiotherapy in the treatment of nasopharyngeal carcinoma, and would not increase the adverse reactions. It was worthy of clini-cal application as well as further study.

关 键 词：鼻咽癌 多西紫杉醇 放疗增敏 

分 类 号：R739.63[医药卫生—肿瘤]