环氧化酶-2基因多态性与膀胱癌的易感性研究  

Relationship between polymorphism of COX-2 and susceptibility of bladder cancer

作　　者：覃茜[1] 覃健[1] 白先忠[2] 蒙清贵[2] 程继文[2] 陆浩源[2] 

机构地区：[1]广西医科大学公共卫生学院、劳动卫生与环境卫生学教研室,南宁市530021 [2]广西医科大学附属肿瘤医院泌尿外科,南宁市530021

出　　处：《实用医学杂志》2014年第7期1076-1079,共4页The Journal of Practical Medicine

基　　金：广西自然科学基金资助项目(编号:2011GXNSFB018080)

摘　　要：目的:探讨环氧化酶-2(cyclooxygenase-2,COX-2)3′非翻译区的8473(T/C,rs5275)位点的基因多态性与膀胱癌发病风险的相关性。方法:采用病例-对照研究方法,运用Taqman SNP Genotyping Assays检测研究对象的COX-2基因rs5275的多态性,分析该位点多态性与膀胱癌的关系。结果:COX-2的rs5275位点基因型在膀胱癌组和正常对照组中分布差异有统计学意义(P<0.05),TC/CC基因型在膀胱癌组中的分布频率显著低于正常对照组(校正后OR值分别为:0.178,0.087;95%CI:0.119～0.264,0.058～0.129;),C等位基因携带者在膀胱癌组的频率低于正常对照组(校正后OR=0.122;95%CI:0.082～0.181);rs5275位点多态性与性别、吸烟有关(校正后OR值分别为:2.125,0.476;95%CI分别为:1.500～3.010,0.325～0.696);膀胱癌组TT基因型与TC/CC与膀胱癌的病理特征之间差异无统计学意义(P>0.05)。结论:COX-2的rs5275位点多态性的单独效应可能与膀胱癌易感性有关,CT/CC基因型可能是其保护因素。Objective To investigate the correlation of polymorphism of 8473 （T/C, rs5275） in the Y- untranslated region of cyclooxygenase-2 （COX-2） gene with bladder cancer. Methods A case-control study on the relation between COX-2 polymorphism and bladder cancer was performed in this study. The Taqman SNP genotyping assay was used to study the COX-2 rs5275 polymorphism. Results The differences in allele or genotype distributions of COX-2 rs5275 between cases and controls （all P 〈 0.05） were significant. A significantly reduced risk was revealed in bladder cancer patients carrying the TC genotype （adjusted OR =0.178;95%CI：0.119 -0.264）,CC genotype （adjusted OR = 0.087; 95%CI：0.058 - 0.129） or （TC/CC） genotype （adjusted OR = 0.122;95%CI： 0.082-0.181 ） compared to the control group. Significant difference in genotype distribution of the COX-2 rs5275 site was found associated with sex and smoking （adjusted OR：2.125,0.476;95% CI： 1.500 3.010,0.325- 0.696）;No corelation was found between genetype Tr or TC/CC and the pathological features of bladder cancer （P 〉 0.05）. Coulusion The separate effect of rs5275 polymorphism of COX-2 is associated with the susceptibility of bladder cancer, the TC/CC genotvpes may be a orotective factor.

关 键 词：膀胱肿瘤 环氧化酶-2 基因多态性 

分 类 号：R737.14[医药卫生—肿瘤]