BAG-1、p53表达与NSCLC新辅助化疗疗效分析  

Expression of BAG-1 and p53 in relation to efficacy of neo-adjuvant chemotherapy in patients with NSCLC

作　　者：曾辉[1] 龚晓成 韩建伟[1] 许朝阳[2] 

机构地区：[1]浙江大学医学院附属第二医院建德分院胸外科,浙江建德311600 [2]浙江大学医学院附属第二医院建德分院病理科,浙江建德311600

出　　处：《实用肿瘤杂志》2014年第2期169-172,共4页Journal of Practical Oncology

摘　　要：目的探讨Ⅲ期非小细胞肺癌(NSCLC)患者BAG-1、p53蛋白表达与新辅助化疗疗效之间的关系。方法通过免疫组织化学法检测57例Ⅲ期NSCLC患者BAG-1、p53蛋白表达水平,并研究上述指标的表达与新辅助化疗疗效之间的关系。结果 BAG-1的表达与NSCLC的分化程度有关(P<0.05),BAG-1与p53蛋白的表达无相关性(r=-0.136,P>0.05)。BAG-1表达与新辅助化疗疗效无相关性(P>0.05),p53表达与新辅助化疗疗效无相关性(P>0.05),BAG-1与p53共同表达与新辅助化疗疗效无相关性(P>0.05)。结论化疗前Ⅲ期NSCLC患者BAG-1与p53均表达阳性者较阴性者新辅助化疗有效率低,但差异无统计学意义。Objective To investigate the relationship of the expression of BAG-1 and p53 and the efficacy of neoadjuvant chemotherapy in patients with stage III non-small cell lung cancer （NSCLC）. Methods Fifty seven patients with stage III NSCLC receiving neo-adjuvant chemotherapy were enrolled in the study. The expression of BAG-1 and p53 was detected by immunohistochemistry and the correlation of the expression of BAG-1 and p53 and the response rate of chemotherapy was analyzed. Results The expression of BAG-1 was significantly correlated with the differentiated degree of NSCLC（P 〈0, 05 ）. The expression of BAG-1 and p53 was not correlated with each other（ r = - 0. 136,P 〉 0.05 ）. The expression of both BAG-I and p53 was not correlated with the efficacy of neo-adjuvant chemotherapy （ P 〉 0. 05 ）. Conclusion The expression of BAG-1 and p53 has no correlation with the response rate of neo-adjuvant chemotherapy in patients with stage III NSCLC.

关 键 词：癌 非小细胞N 药物疗法 化学疗法 辅助 载体蛋白质类 基因 p53 基因表达 治疗结果 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]