原发性高血压24 h尿钠与微量白蛋白尿关系研究  

Relationship between urinary sodium excretion and microalbuminuria in essential hypertension

作　　者：刘欢[1] 钟健[1] 何洪波[1] 闫振成[1] 祝之明[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所高血压内分泌科全军高血压代谢病中心重庆市高血压研究所,重庆400042

出　　处：《中国实用内科杂志》2014年第4期387-390,共4页Chinese Journal of Practical Internal Medicine

基　　金：973项目(2012CB517805);第三军医大学临床医学重大科研项目(2012XLC08)

摘　　要：目的探讨原发性高血压患者尿钠与微量白蛋白尿的关系。方法选择2011年11月至2013年10月在第三军医大学附属第三医院住院治疗的原发性高血压患者418例。根据24 h尿钠的四分位数,将入选人群分为低尿钠组、低中尿钠组、中高尿钠组和高尿钠组,用单因素方差分析比较4组的一般临床资料、血清学指标和24 h尿钠、尿微量白蛋白,用多元线性回归分析影响24 h尿微量白蛋白的危险因素。结果随着24 h尿钠的升高,原发性高血压患者24 h尿微量白蛋白随之升高(P<0.01)。多元线性回归分析结果提示24 h尿钠是原发性高血压患者微量白蛋白尿的独立危险因素[OR(95%CI):0.437(0.264,0.611),P<0.001]。结论 24 h尿钠是原发性高血压患者微量白蛋白尿的独立危险因素,控制钠盐摄入有利于防治高血压肾脏病变。Objective To investigate the impacts of urinary sodium on microalbuminuria in patients with essential hyperten- sion. Methods A total of 418 in-patients with essential hypertension were enrolled. The subjects were divided into 4 groups according to the quartiles of 24-hour urinary sodium. One-way ANOVA was performed to analyze general clinical data, serum markers ,24-hour urinary sodium and microalbumin. Multiple linear regression analysis was performed to investigate the in- dependent risk factors of increasing 24-hour urinary microalbumin. Results 24-hour urinary microalbumin increased signif- icantly with 24-hour urinary sodium （ P 〈 0. 01 ）. Multiple linear regression analysis showed that 24-hour urinary sodium was the independent risk factor of 24-hour urinary microalbumin （ OR [ 95 % CI ] ：0. 437 [ 0. 264,0. 611 ], P 〈 0. 001 ）. Conclu- sion Elevated urinary sodium independently increases the risk of microalbuminuria in patients with essential hypertension. Control of sodium intake is helpful to prevent kidney damage induced by hypertension.

关 键 词：高血压 尿钠 尿微量白蛋白 钠盐 

分 类 号：R544[医药卫生—心血管疾病]