齐拉西酮和利培酮治疗精神分裂症比较研究  

Study on comparison of ziprasidone and risperidone in treating patients with schizophrenia

作　　者：汪琳[1] 张涛[1] 白克镇 邹文华[2] 

机构地区：[1]泸州医学院附属医院,四川泸州646000 [2]湖南省长沙市精神病医院,湖南长沙410007

出　　处：《现代中西医结合杂志》2014年第12期1279-1281,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的比较齐拉西酮和利培酮治疗精神分裂症的疗效及对患者生化指标的影响。方法将65例精神分裂症患者按照治疗方式不同分为齐拉西酮组和利培酮组,分别采用齐拉西酮和利培酮治疗8周,采用阳性与隐性症状量表(PANSS)和副作用量表(TESS)评定2组疗效和不良反应,并对患者实验室指标进行分析。结果治疗2周后,齐拉西酮组和利培酮组PANSS评分较治疗前均显著下降(P均<0.05)。治疗后2组同时间点PANSS总分、阳性症状分、阴性症状分及一般精神病理分比较无显著性差异(P均>0.05)。2组治疗有效率比较无显著性差异(P>0.05)。齐拉西酮组不良反应发生率较利培酮组低(P<0.05)。齐拉西酮组治疗前后体质量、血糖和血脂比较无显著性差异(P>0.05)。利培酮组治疗后体质量、血糖和血脂较治疗前显著升高(P均<0.05)。治疗后利培酮组同时间点体质量、血糖和血脂水平明显高于齐拉西酮组(P均<0.05)。结论齐拉西酮和利培酮治疗精神分裂症疗效相当,但齐拉西酮安全性高,对患者体质量和代谢指标影响小。Objective It is to compare the effect and the influence on metabolism index of ziprasidone and risperidone in treating patients with schizophrenia .Methods 65 patients with schizophrenia were randomly divided into ziprasidone group and risperidone group .Patients were treated with ziprasidone in ziprasidone group and with risperidone in risperidone group for 8 weeks.The curative effect and adverse reaction was assessed by using Positive and Negative symptom scale （ PANSS） and Treatment Emergent Symptom Scale （ TESS ） , and the metabolism index in both group were analyzed .Results The PANSS scores in ziprasidone group and risperidone group in the 2nd week were significantly reduced than that before treatment （P0.05）.The effect of ziprasidone group and risperidone group had no significantly difference （P〉0.05）.The incidences rate of side effect in ziprasidone group were significantly lower than that in risperidone group （all P0.05）.After treat-ment, the body weight , blood glucose and blood lipid in risperidone group were significantly higher than that in ziprasidone group （all P〈0.05）.Conclusion Ziprasidone has the similar therapeutic effect to risperidone in the treatment of schizophre -nia.However , Ziprasidone have well-tolerated and low effect on serum glucose and lipid metabolism .

关 键 词：齐拉西酮 利培酮 精神分裂症 代谢指标 

分 类 号：R749.3[医药卫生—神经病学与精神病学]