急性视网膜坏死发病机制的研究进展  

Research advance in mechanism of acute retinal necrosis

作　　者：刘鑫(综述)[1] 苏冠方[1] 赵劲松(审校)[1] 

机构地区：[1]吉林大学第二医院眼科,长春130041

出　　处：《中华实验眼科杂志》2014年第4期365-369,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目（31071222）、白求恩医学科研支持计划

摘　　要：急性视网膜坏死（ARN）是一种少见的病毒感染性疾病,其致病病毒主要是疱疹病毒,易引起视网膜脱离等并发症,故视力预后较差.ARN的发生和发展主要为感染与抗感染的过程,包括病毒入侵、播散、潜伏活化及机体免疫应答等方面.病毒进入宿主细胞是病毒表面蛋白与宿主细胞表面受体结合的过程,病毒感染后可潜伏于眼部相关的神经组织及眼内组织中.研究表明,病毒感染后可活化机体的免疫系统,诱发免疫细胞吞噬病毒、活化其他免疫细胞、产生细胞因子并介导炎症反应等,从而起到清除病毒、控制感染的目的,这些免疫细胞及细胞因子相互作用,共同参与ARN的发病过程.就病毒入侵、播散及机体免疫等与ARN发生和发展的关系进行综述.Acute retinal necrosis （ARN） syndrome is a kind of rare eye infectious disease caused by herpetic virus primarily.Visual prognosis of ARN patient is poor because of a high rate of complications including retinal detachment.The infection and antiinfection runs through the pathological process in ARN,such as invasion and dissemination of virus as well as the immunologic response of body.The multiple mechanisms are associated with the entry and spread of virus,including binding of viral surface protein and host receptor.Establishment of latency of the virus relies on access to related neuron,ganglion,ocular tissue which may occur after initial entry and replication.Activation of the immunologic system makes it possible to eliminate the virus and control infection.The relationship of viral invasion,dissemination and immune response with ARN pathogenesis and progression were reviewed.

关 键 词：急性视网膜坏死 病毒学 单纯疱疹 病毒学 眼部感染 病毒 病毒学 病毒潜伏 视网膜疾病 免疫 细胞因子 

分 类 号：R774.1[医药卫生—眼科]