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作 者:陈旭梅[1] 朱琪玥 张伟[2] 李雪[1] 郝以辉[1] 李幼辉[1] 吕路线[3] 宋学勤[1]
机构地区:[1]郑州大学第一附属医院精神医学科,450052 [2]郑州大学教育系 [3]河南省生物精神病学重点实验室新乡医学院第二附属医院
出 处:《中华医学杂志》2014年第13期990-993,共4页National Medical Journal of China
基 金:国家自然科学基金(30971058,81071090);河南省科技攻关项目(132102310136);郑州大学研究生科学研究项目(12Y03410)
摘 要:目的 探讨首发精神分裂症患者血清叶酸、同型半胱氨酸水平及其与认知功能之间的关系.方法 选取2012年10月至2013年6月就诊于郑州大学第一附属医院的60例首发未用药精神分裂症患者(患者组)和同期的健康对照者(对照组)60名,采用电化学免疫发光法和循环酶法分别测定受试者血清叶酸和同型半胱氨酸水平,阳性和阴性症状量表(PANSS)评定患者组入组时精神症状,精神分裂症认知功能成套测验(MCCB)评估患者入组时的认知功能.结果 患者组血清叶酸水平[(4.1 ±1.9) ng/ml]低于对照组[(7.5±1.9)ng/ml] (P <0.001);同型半胱氨酸水平患者组[(27 ±9)μmol/L]高于对照组[(18±6)μmol/L] (P =0.006);相关分析显示,患者组叶酸水平和同型半胱氨酸水平呈负相关(r=-0.38,P=0.002),患者组血清叶酸水平与阴性症状呈负相关(r=-0.25,P<0.05),患者血清同型半胱氨酸水平与连线测验分呈正相关(r=0.28),与霍普金斯词语学习测验分、简易视觉记忆测验分、Stroop色词测验分和持续操作测验评分呈负相关(r=-0.38,r=-0.33,r=-0.30,r=-0.30,均P<0.05).结论 首发精神分裂症患者血清叶酸水平降低,同型半胱氨酸水平升高,与患者精神症状和认知功能的损害程度存在一定相关性.Objective To explore the correlation between serum levels of homocysteine (Hcy) and folate and cognitive function in first-episode drug-naǐve schizophrenics.Methods A total of 60 first-episode schizophrenics (schizophrenia group) from our hospital and 60 healthy individuals (control group) were enrolled.Serum levels of folate and Hcy were measured with electrochemical luminescence method and enzymatic cycling assay respectively.Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms and Matrics Consensus Cognitive Battery (MCCB) was used to evaluate the cognitive function.Results Serum level of folate in schizophrenia group (4.1 ± 1.9 ng/ml) was lower than that in control group (7.5 ± 1.9 ng/ml) (P < 0.001).And serum level of Hcy in schizophrenia group (27 ± 9 μmol/L) was significantly higher than that in control group (18 ± 6 μmol/L) (P =0.006).Serum level of folate in schizophrenia group had negative correlations with Hcy level (r =-0.38,P =0.002) and negative symptoms (r =-0.25,P < 0.05) while Hcy level was negatively correlated with cognitive function scores (r=-0.38,r =-0.33,r =-0.30,r =-0.30,P <0.05).Conclusion Serum level of folate decreases while serum level of Hcy increases in first-episode schizophrenics.Both have some relevance with mental symptom and cognitive dysfunction.
分 类 号:R749.3[医药卫生—神经病学与精神病学]
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