HBV X蛋白引起肝细胞癌异常表观遗传学修饰  

HBV X protein induces abnormal epigenetic modifications in hepatocellular carcinoma

作　　者：倪东京[1] 张梦洁[1] 杨爽[1,2] 

机构地区：[1]第三军医大学全军免疫学研究所,重庆400038 [2]贵州省遵义县人民医院内科,遵义563100

出　　处：《免疫学杂志》2014年第4期351-354,共4页Immunological Journal

基　　金：国家自然科学基金面上项目(31070798;31200668);"973"项目(2013CB531503)

摘　　要：肝细胞癌(HCC)是最常见的恶性肿瘤之一,与HBV的慢性感染密切相关。HBV X蛋白(HBx)由HBV x基因编码,研究表明它在HBV相关肝细胞癌的形成中起着重要作用。HBx可以引起宿主基因表观遗传修饰的显著改变,有证据已经表明由HBx引起的表观遗传学事件在HBV相关肝细胞癌的发展中起着重要作用。本综述主要关注HBx在肝细胞癌中引起的表观遗传学变化,包括异常的DNA甲基化、组蛋白修饰和microRNAs表达;对HBx引起HBV共价闭合环状(ccc)DNA的表观遗传学调控也进行了讨论。Hepatocellular carcinoma is one of the most common malignant tumors and closely associates with chronic HBV infection. HBV X protein （HBx）, encoded by HBV x gene, plays an important role in the onset and progression of HBV related hepatocellular carcinoma. Evidence has indicated that the epigenetic events caused by HBx can induce significant changes in the epigeneties of host genes, thus play important roles in the development of HBV-related HCC. This review focuses on the HBx-induced abnormal epigenetic changes including DNA methylation, histone modifications and microRNAs expression in HCC. We also discuss the HBx-induced epigenetie regulation of HBV covalently-closed circular DNA.

关 键 词：肝细胞癌 HBVX蛋白 DNA甲基化 组蛋白修饰 MICRORNAS 

分 类 号：R735.7[医药卫生—肿瘤]