体素内不规则运动磁共振成像在肝纤维化评估中的初步应用  

Preliminary application of intravoxel incoherent motion MR imaging for evaluation of liver fibrosis

作　　者：柴维敏[1] 严福华[1] 王鹤 侯亮[1] 罗先富[1] 张菁 朱乃懿[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院放射科,上海200025 [2]飞利浦医疗(苏州)有限公司,江苏苏州215024 [3]上海大华医院中医肝科,上海200237

出　　处：《诊断学理论与实践》2014年第1期77-81,共5页Journal of Diagnostics Concepts & Practice

基　　金：上海市卫生局课题(2010040);上海市高校一流学科(B类);国家临床重点专科项目

摘　　要：目的:研究体素内不规则运动(intravoxel incoherent motion,IVIM)磁共振成像(magnetic resonance imaging,MRI)技术在肝纤维化评估中的应用价值。方法:对41例进展期肝纤维化患者与11例正常对照者(对照组)行IVIMMRI扫描,测量标准表观弥散系数(standard apparent diffusion coefficience,staADC)值、fast ADC(fADC)值、slow ADC(sADC)值、fraction ADC(fra ADC)值,并与血清学肝纤维化相关指标行相关性研究。结果:肝纤维化组与对照组间的fra ADC值、sADC值差异有统计学意义(P<0.05),staADC值、fADC值差异无统计学意义。肝纤维化组γ谷氨酰转移酶(gamma-glutamyl transferase,GGT)与staADC值、铁蛋白与staADC呈中度负相关性,铁蛋白与sADC呈中、高度负相关性,铁蛋白与fraADC呈中度正相关性;透明质酸与fADC呈负相关性。结论:IVIM-MRI技术作为临床肝纤维化疾病评估手段具有一定价值。Objective： To study the value of intravoxel incoherent motion （IVIM） MRI technique for evaluation of liver fibrosis. Methods： Forty-one patients with advanced liver fibrosis and 11 healthy volunteers were enrolled and IVIM- MRI scanning was performed. Standard ADC value（staADC）, fast ADC value（fADC）, slow ADC value （sADC）, fraction ADC value （fra ADC）were measured, and correlations between these parameters and serum liver fibrosis indexes were studied. Results： There was statistically significant difference in fraADC value and sADC value between patients and the controls （P〈0.05）, and no significant difference was seen in staADC, fADC . Moderate negative correlation was seen between GGT and staADC value, ferritin and staADC value, respectively. Serum ferritin had moderate to high negative correlation with sADC value, and had moderate positive correlation with fraADC value. Hyaluronic acid had negative correlation with fADC value. Conclusions： IVIM-MRI technique could be a useful method for evaluating liver fibrosis clinically.

关 键 词：磁共振 体素内不规则运动 肝纤维化 评估 

分 类 号：R575.29[医药卫生—消化系统]