Role of human leukocyte antigen molecules in selecting potential donors for allogeneic hematopoietic stem cell transplantation  

作　　者：He Jun 

机构地区：[1]Department of HLA Laboratory, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou,Jiangsu 215006, China

出　　处：《Chinese Medical Journal》2014年第7期1377-1381,共5页中华医学杂志（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （No.81072435; 81273266）,the Outstanding Medical Academic Leader Program of Jiangsu Province （No.LJ 201138）,the Science and Technology Key Project on Clinical Medicine of Jiangsu Province （No.BL2013013）,and the Key Laboratory Foundation of Suzhou （No.SZS201001; SZS0702）.

摘　　要：Allogeneic hematopoietic stem cell transplantation （alloHSCT） has been used to treat a variety of hematologic malignancies and non-malignant diseases.Hematopoietic stem cell donor selection is based on identical human leukocyte antigen （HLA） related or unrelated donor matching with the recipient.Donor-recipient HLA mismatching has been associated with graft-versus-host disease （GVHD）,increased mortality and decreased disease free survival （DFS）.1 Not all patients are able to find a suitable donor,as no more than 25% of patients have an HLA-identical sibling.Much effort has been devoted to the establishment of bone marrow （BM） registries for HSCT.Keywords：human leukocyte antigen; transplantation; donor; genotypingAllogeneic hematopoietic stem cell transplantation （alloHSCT） has been used to treat a variety of hematologic malignancies and non-malignant diseases.Hematopoietic stem cell donor selection is based on identical human leukocyte antigen （HLA） related or unrelated donor matching with the recipient.Donor-recipient HLA mismatching has been associated with graft-versus-host disease （GVHD）,increased mortality and decreased disease free survival （DFS）.1 Not all patients are able to find a suitable donor,as no more than 25% of patients have an HLA-identical sibling.Much effort has been devoted to the establishment of bone marrow （BM） registries for HSCT.Keywords：human leukocyte antigen; transplantation; donor; genotyping

关 键 词：human leukocyte antigen TRANSPLANTATION DONOR GENOTYPING 

分 类 号：R457.7[医药卫生—治疗学]