多系统萎缩^131I-间碘苄胍心肌显像初步研究  

Cardiac131I-MIBG scintigraphy in patients with multiple system atrophy

作　　者：王丽[1] 杨团峰[1] 程敏[1] 李原[2] 王茜[2] 焦劲松[3] 顾卫红[3] 王康[3] 金淼[3] 郭淮莲[1] 

机构地区：[1]北京大学人民医院神经内科,100044 [2]北京大学人民医院核医学科 [3]卫生部中日友好医院神经内科,北京100029

出　　处：《中国现代神经疾病杂志》2014年第3期257-262,共6页Chinese Journal of Contemporary Neurology and Neurosurgery

摘　　要：研究背景131I-间碘苄胍(131I-MIBG)可被心脏交感神经节后纤维摄取,是评价心脏交感神经功能的显像剂。本研究采用131I-MIBG心肌显像方法,探讨多系统萎缩患者自主神经功能障碍。方法共12例符合2008年第2版诊断标准的多系统萎缩患者和7例正常对照者,通过统一多系统萎缩评价量表进行病情严重程度评价,静脉注射131I-MIBG 3 mCi后于不同测量时间点(15 min、4 h和24 h)采集胸部前位平面像,计算131I-MIBG心肌摄取率。结果注射131I-MIBG后15 min和4 h,多系统萎缩组患者131I-MIBG心肌摄取率均低于正常对照组(15 min:1.90±0.41对2.38±0.32,P=0.017;4 h:1.96±0.63对2.60±0.55,P=0.039)。结论多系统萎缩组患者131I-MIBG心肌摄取率低于正常对照组,提示多系统萎缩可以发生心脏交感神经变性。Background ^131I-metaiodobenzylguanidine （^131I-MIBG） can be intaked by cardiac sympathetic postganglionic fibre, thus becomes the imaging agent to evaluate cardiac sympathetic nerve function. The aim of this study is to investigate the autonomic nerve dysfunction of patients with multiple system atrophy （MSA） by using cardiac^131I-MIBG scintigraphy. Methods Clinical data of 12 MSA patients conforming to the ＂secord consensus statement on the diagnosis of MSA was analyzed by Unified Multiple System Atrophy Rating Scale （UMSARS）. ^131I- MIBG scintigraphy was performed in 12 MSA patients and 7 age-matched controls. Planar images of the chest were obtained 15 rain, 4 h and 24 h after the intravenous injection of 3 mCi ^131I-MIBG. Cardiac 131I-MIBG uptake was quantified by comparing region of interest （ROI） over heart/mediastinum （H/M） ratio. Results Cardiac ^131I-MIBG uptake ratio in MSA group was significantly less than that in control group in 15 rain （1.90 ± 0.41 vs 2.38 ± 0.32, P = 0.017） and 4 h （1.96 ± 0.63 vs 2.60 ± 0.55, P = 0.039）. There were significant difference （P 〈 0.05） between MSA group and control group. Conclusions Cardiac ^131I-MIBG uptake ratio in MSA group was less than that in control group. This finding suggests cardiac sympathetic degeneration may occur in MSA patients.

关 键 词：多系统萎缩 交感神经系统 ^131I-间碘苄胍(非MeSH词) 

分 类 号：R746[医药卫生—神经病学与精神病学]