肿瘤治疗新靶点:碱性成纤维细胞生长因子及其受体信号  

New target for cancer therapy: basic fibroblast growth factor and its receptor signaling

作　　者：陈文慧[1] 徐萌[1] 

机构地区：[1]暨南大学附属第一医院肿瘤科,广州市510632

出　　处：《中国肿瘤临床》2014年第7期466-470,共5页Chinese Journal of Clinical Oncology

基　　金：国家高技术研究发展计划(863计划)资助项目(编号:2009AA02Z112);国家自然科学基金资助项目(编号:81273814)资助~~

摘　　要：碱性成纤维细胞生长因子(bFGF)是一个促细胞分裂、增殖及血管生成的多肽生长因子,肿瘤组织中bFGF及其受体过度表达为抗肿瘤治疗提供潜在靶目标,研制靶向性抗bFGF抗体、FGFR抑制剂等抑制肿瘤细胞增殖和新血管形成,阻断肿瘤生长的营养和转移途径,成为抗肿瘤热点。本文就bFGF及其受体信号在肿瘤的发生、发展和转移中的作用及临床转化研究进行综述。Basic fibroblast growth factor （bFGF） is a kind of polypeptide that serves an important function in mitogen, prolifera- tion, and angiogenesis, bFGF is a potential anti-cancer therapy target and its receptor is highly expressed in tumor tissue. Antitumor drugs such as anti-bFGF antibody and FGFR antagonists are being developed to block tumor growth and metastasis. In this paper, bF- GF and its receptor signaling pathway in tumor development and metastasis is investigated, and clinical translational research is reviewed.

关 键 词：BFGF FGFR 信号转导 临床转化研究 

分 类 号：R730.5[医药卫生—肿瘤]