肠神经胶质细胞在炎症性肠病发生发展中作用的研究进展  

Role of enteric glial cells in infl ammatory bowel disease

作　　者：齐国卿[1] 谢瑞霞[1] 张德奎[1] 

机构地区：[1]兰州大学第二医院消化内科,甘肃省兰州市730000

出　　处：《世界华人消化杂志》2014年第8期1076-1080,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81272661~~

摘　　要：目前炎症性肠病(inflammatory bowel disease,IBD)病因及发病机制尚不清楚,大多数学者认为持续肠道感染、肠黏膜屏障缺损、肠黏膜免疫调节异常、遗传和环境等因素共同参与了其发生过程.近来有研究显示肠神经胶质细胞在维持肠黏膜屏障的完整方面发挥重要作用,肠神经胶质细胞的缺失会导致小鼠肠黏膜屏障完整性丧失,通透性增加,产生肠道炎症,出血及坏死等IBD的表现.本文就肠神经胶质细胞在IBD发生发展中的作用研究现状作一综述.The etiology and pathogenesis of inflammatory bowel disease are currently unknown. It is gener- ally believed that persistent intestinal infection, in- testinal mucosal barrier defect, intestinal mucosal immune dysregulation and genetic and environ- mental factors together contribute to the pathogen- esis of inflammatory bowel disease. Several studies have demonstrated that enteric glial cells play an important role in maintaining the integrity of intes- tinal mucosal barrier. Enteric glial cell deficiency in mice leads to the destruction of integrity of intestinal mucosal barrier, increases mucosal per- meability, and results in intestinal inflammation, hemorrhage and necrosis. This article discusses the role of enteric glial cells in the occurrence and development of inflammatory bowel disease.

关 键 词：肠神经胶质细胞 炎症性肠病 溃疡性结肠 炎 克罗恩病 

分 类 号：R574[医药卫生—消化系统]