抑癌基因甲基化与结直肠癌临床关系的研究进展  

Relationship between methylation of tumor suppressor genes and colorectal cancer

作　　者：柴秀坤 剧宏燕[1] 白文元[1] 

机构地区：[1]河北医科大学第二医院消化内科,河北省石家庄市050000

出　　处：《世界华人消化杂志》2014年第8期1087-1092,共6页World Chinese Journal of Digestology

摘　　要：结直肠癌(colorectal cancer,CRC),也称大肠癌是世界上发病率和死亡率均排第3位的恶性肿瘤性疾病,严重威胁着人类健康.随着人们生活水平的提高,饮食习惯和结构的改变,其发病率和死亡率增长迅速.近年来抑癌基因异常甲基化成为CRC的研究热点,他参与了肿瘤的发生、发展全过程.抑癌基因甲基化可广泛应用于CRC早期筛查和诊断、有效治疗、监测复发和转移及预后评估等,与CRC临床关系密切.本文主要从抑癌基因甲基化与CRC临床关系及其临床意义方面的研究进展做一简要综述.Colorectal cancer is ranked third both in inci- dence and mortality rate among malignant tumor diseases worldwide, posing a serious threat to human health. The improvement of people＇s liv- ing standards and changes in dietary habits and structure have led to a rapid increase in the inci- dence and mortality rate of colorectal cancer. The methylation of tumor suppressor genes （TSGs） participates in the genesis and progression of colorectal cancer and has become a hotspot in colorectal cancer research in recent years. Eluci- dation of the clinical significance of methylation of TSG can be helpful in the early screening and diagnosis, recurrence and metastasis monitoring, effective treatment, and evaluation of prognosis of this malignancy. This article reviews the recent progress in understanding the relationship be- tween TSG methylation and colorectal cancer.

关 键 词：抑癌基因 甲基化 结直肠癌 CIMP 临床意义 

分 类 号：R735.3[医药卫生—肿瘤]