Ki-67和p130在肝细胞癌穿刺组织中的表达对TACE治疗的临床意义  

Clinical significance of Ki-67 and p130 expression in liver needle biopsy from patients with hepatocellular carcinoma treated by transcatheter arterial chemoembolization

作　　者：苏赓[1] 马亦龙[2] 欧盛秋[2] 赵昌[2] 宋庆峰[2] 

机构地区：[1]广西壮族自治区民族医院病理科,广西壮族自治区南宁市530001 [2]广西医科大学附属肿瘤医院介入科,广西壮族自治区南宁市530021

出　　处：《世界华人消化杂志》2014年第8期1146-1152,共7页World Chinese Journal of Digestology

基　　金：广西壮族自治区卫生厅科研计划基金资助项目;No.z.2013282~~

摘　　要：目的:检测Ki-67和p130在肝细胞癌(hepatocel-lular carcinoma,HCC)穿刺组织中的表达对经导管肝动脉化疗栓塞(transcatheter arterial chemoembolization,TACE)治疗的肝细胞患者的临床意义.方法:对我院2005-01/2010-08行介入治疗的41例肝细胞癌患者临床资料、诊疗方法及结果进行回顾性分析,用免疫组织化学SP法检测肝细胞癌穿刺组织中Ki-67和p130表达情况.结果:Ki-67和p130在肝细胞癌穿刺组织中的表达率分别为63.41%(26/41)和51.52%(21/41);Ki-67和p130的表达与病理分期和肿瘤预后相关(P<0.05),与患者性别、年龄、肿瘤大小、TNM分期和血清AFP值不相关(P>0.05);Ki-67和p130在肝细胞癌中的表达呈负相关系(r=-0.371,P<0.05);经TACE治疗的肝细胞癌患者预后与Ki-67和p130的表达及TNM分期相关(P<0.05),而与患者性别、年龄、肿瘤大小、病理分期和血清AFP值均不相关(P>0.05).结论:Ki-67和p130的表达在肝细胞癌的发生发展中起着重要作用,Ki-67和p130的表达可作为TACE治疗的肝细胞癌患者预后的重要分子标志物.AIM： To investigate the clinical significance of Ki-67 and p130 expression in liver needle biopsy from pa- tients with hepatocellular carcinoma （HCC） treated by transcatheter arterial chemoembolization （TACE）.METHODS： Medical records for 41 HCC pa- tients treated by TACE between January 2005 and August 2010 were reviewed and the major clinical features, treatment modalities and out- comes were analyzed. The protein expression of Ki-67 and p130 was detected by S-P immunohis- tochemical method in 41 liver needle biopsies from patients with HCC. RESULTS： The total positive rates of Ki-67 and p130 expression in HCC were 63.41% （26/41） and 51.52% （21/41）, respectively. The expression of Ki-67 and p130 proteins was related to histo- logical grade and prognosis （P 〈 0.05 for both）, but not to sex, age, tumor size, TNM stage or serum level of AFP （P 〉 0.05 for all）. There was a significant negative correlation between Ki-67 and p130 protein expression （r = -0.371, P 〈 0.05）. The prognosis of the 41 patients with HCC treated by TACE was related to TNM stage and expression of Ki-67 and p130 （P 〈 0.05 for all）, but not to sex, age, tumor size, histological grade or serum level of AFP （P 〉 0.05 for all）. CONCLUSION： Ki-67 and p130 play important roles in occurrence and development of HCC. Ki-67 and p130 can be used as predictive mark- ers for HCC patients treated with TACE.

关 键 词：肝细胞癌 活检 化疗栓塞 KI-67 P130 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]