非酒精性脂肪性肝病合并自身免疫异常132例  

Non-alcoholic fatty liver disease complicated with autoimmune problems:Analysis of 132 cases

作　　者：吴凤娟[1] 徐芸[1] 保洁 刘象 

机构地区：[1]郑州大学第一附属医院消化内科河南省高等学校临床医学重点学科开放实验室,河南省郑州市450052

出　　处：《世界华人消化杂志》2014年第9期1294-1299,共6页World Chinese Journal of Digestology

摘　　要：目的:分析非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)与自身免疫异常的关系.方法:经肝活检确诊的NAFLD患者132例分为NAFLD合并自身免疫性肝病(autoimmune liver diseases,AILD)组、NAFLD合并其他自身免疫性疾病(除外AILD)组、NAFLD合并自身免疫现象组、NAFLD组.收集各组研究对象临床生化、自身抗体、影像学及肝组织学指标,应用SPSS17.0进行统计学分析.结果:AST组1与组4之间比较差异有统计学意义(P<0.05),血清免疫球蛋白G(immunoglobulin G,IgG)组1、组2、组3分别与组4比较差异均有统计学意义(P<0.05),肝脏硬度值、肝纤维化、炎症程度组1分别与组2、组3、组4比较差异均有统计学意义(P<0.05).结论:IgG、肝脏硬度值、肝纤维化和炎症程度与自身免疫异常严重程度有关,IgG和肝脏硬度值可作为长期随访指标.AIM： To analyze the relationship between non- alcoholic fatty liver disease （NAFLD） and auto- immune diseases. METHODS： One hundred and thirty-two pa- tients with biopsy-proven NAFLD were divided into four groups： 1 [patients with NAFLD and autoimmune liver disease （AILD）], 2 （patients with NAFLD and autoimmune disease except AILD）, 3 （patients with NAFLD and autoim- mune phenomena） and 4 （patients with NAFLD alone）. All data on clinical and biochemistry indexes, autoantibodies, imaging findings and liver histology were analyzed. RESULTS： The difference in AST was statisti-cally significant between groups 1 and 4 （P 〈 0.05）. There were significant differences in IgG in groups 1, 2 and 3 compared with group 4 （P 〈 0.05 for all）. Liver stiffness, fibrosis stage and inflammation level were different significantly between group I and groups 2, 3 and 4 （P 〈 0.05 for all）. CONCLUSION： The levels of IgG, liver stiffness, liver fibrosis and hepatic inflammation were cor- related with the severity of autoimmune prob- lems. IgG and liver stiffness may act as long- term follow-up indicators.

关 键 词：非酒精性脂肪性肝病 自身免疫性肝病 肝活检 

分 类 号：R575.5[医药卫生—消化系统]