脂肪肝患者肝脏剪切波速度与实验室指标的关系  

Virtual touch tissue quantification and biochemical indicators for quantitative diagnosis of fatty liver

作　　者：王宇[1,2] 李广霞[1,2] 李素梅[1,2] 邹松平[1,2] 靳元[1,2] 

机构地区：[1]大庆龙南医院 [2]齐齐哈尔医学院第五附属医院物理诊断科B超室,黑龙江省大庆市163453

出　　处：《世界华人消化杂志》2014年第9期1307-1311,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨脂肪肝患者肝脏剪切波速度与实验室指标的相关性,为其研究提供可参考依据.方法:随机选择共纳入100例我院采用声触诊组织量化技术(virtual touch quantification,VTQ)行肝脏检查的脂肪肝患者及40例正常人群作为观察对象,记录所有受试者肝脏剪切波速度,且均空腹抽取静脉血检测实验室相关指标.结果:100例诊断为脂肪肝患者中,轻度脂肪肝46例,中度脂肪肝32例,重度脂肪肝22例.4组受试者剪切波速度、谷丙转氨酶(alanineaminotransferase,ALT),谷草转氨酶(aspartateaminotransferase,AST),高密度脂蛋白(high-density lipoprotein,HDL-C),低密度脂蛋白(low-density lipoprotein,LDL-C),总胆固醇(total cholesterol,TC),甘油三酯(triglycerides,TG)比较均有差异(P<0.05);其中,对照组与轻度脂肪肝组剪切波速度比较差异不明显(1.05m/s±0.09 m/s vs 1.09 m/s±0.12 m/s,P>0.05).中度脂肪肝肝脏剪切波速度最高(1.32 m/s±0.14 m/s),重度脂肪肝肝脏剪切波速度最低(0.85 m/s±0.07 m/s).轻中度脂肪肝剪切波速度与ALT、AST、HDL-C、LDL-C、TC、TG均存在密切相关性(均P<0.05),其中HDL-C为负相关关系,其余为正相关关系.结论:采用VTQ进行肝脏剪切波速度测定可以更为准确、客观的进行脂肪肝诊断与分度,其操作简便、耗时短;同时肝脏剪切波速度与肝功能及血脂等生化指标存在密切的相关性,VTQ值得临床推广应用.AIM： To explore the value of virtual touch tissue quantification （VTQ） measuring the liver shear wave speed and biochemical indicators in the quantitative diagnosis and classification of fatty live. METHODS： One hundred patients with fatty liver and 40 normal controls were included in the study. The shear wave speed of the liver was measured by VTQ, and alanine aminotransfer- ase （ALT）, aspartate aminotransferase （AST）, triglycerides （TG）, high density lipoprotein （HDL-C） and low density lipoprotein （LDL-C） were measured. The relationship of these quan- titative indexes with fatty liver was analyzed.RESULTS： Among 100 patients with fatty liver, 46 had mild disease, 32 had moderate disease and 22 had severe disease. The values of shear wave speed, ALT, AST, TG, HDL-C and LDL-C were significantly different （P 〈 0.05 for all） between the control and fatty liver groups. The difference in the shear wave speed was not sig- nificant between the normal group and mild fatty liver group （1.05 m/s ± 0.09 m/s vs 1.09 m/s ± 0.12 m/s, P 〉 0.05）. The shear wave speed was the highest in the moderate （1.32 m/s ± 0.14 m/s） and the lowest （0.85 m/s ± 0.07 m/s） in the serve fatty liver group. The shear wave speed in the mild-moderate fatty liver group was closely related with ALT, AST, HDL-C, LDL-C, TC and TG （P 〈 0.05 for all）, of which HDL-C was negatively correlated with the shear wave speed while others were positively correlated with. CONCLUSION： VTQ and biochemical indicators have appreciable value in quantitative diagnosis of fatty liver and provide a reliable and objective basis for clinical diagnosis and treatment of this disease.

关 键 词：脂肪肝 声触诊组织量化技术 剪切波速度 

分 类 号：R575.5[医药卫生—消化系统]