新疆维吾尔族人非酒精性脂肪肝、抵抗素及胰岛素抵抗关系研究  

The study of the relationship between resistin,insulin resistance and non-alcoholic fatty liver in Uygur of Xinjiang

作　　者：王军英[1] 吴荣敏 杨阳 汪应军 姜凯 高亮 

机构地区：[1]石河子大学医学院第一附属医院医务部,石河子832008 [2]新疆维吾尔自治区莎车县人民医院

出　　处：《陕西医学杂志》2014年第3期299-303,共5页Shaanxi Medical Journal

摘　　要：目的:探讨血抵抗素水平与新疆维吾尔族人非酒精性脂肪肝(NAFL)、胰岛素抵抗的关系。方法:选择脂肪肝患者287例(脂肪肝组)和健康对照206例(正常对照组),其中维吾尔族378例,汉族115人,抽取空腹静脉血检测血脂、胰岛素、血糖及抵抗素水平,计算BMI、HOMA-IR,分析抵抗素与NAFL及上述指标的关系。结果:维吾尔族研究对象的脂肪肝构成比、血清抵抗素水平显著高于汉族研究对象。在维吾尔族研究对象中,校正影响因素后,与正常组相比,脂肪肝组血清抵抗素、HOMA-IR水平升高;而脂肪肝患病率、BMI、SBP、TC、LDL-c、HOMA-IR水平随着血清抵抗素的增高呈现上升趋势;Logistic回归分析结果提示:在校正性别、年龄、BMI、SBP、DBP、HOMA-IR、TC、HDL-c、LDL-c、TG等影响因素后,以血清抵抗素三分位最低层为对照,在第二、三分位层时患脂肪肝的OR值分别为7.048、8.085;胰岛素抵抗的OR值分别为2.892、3.699;偏相关分析提示:校正了年龄、性别、SBP、DBP、TG、TC、HDL-c、LDL-c后,HOMA-IR与抵抗素水平正相关。结论:抵抗素水平升高是维吾尔族NAFL的独立危险因素,NAFL患者血抵抗素增高与胰岛素抵抗密切相关。Objective ：To investigate the relationship among resistin ,insulin resistance and Non-Alcoholic Fatty Liver （NAFL） in Uygur of Xinjiang .Methods ：We recruited 287 patients with NAFL （case group） and 206 healthy controls （control group） ,including 378 Uygur and 115 Han individuals .Fasting blood were obtained from all subjects .Then we measured the serum lipids ,insulin ,blood glucose and resistin levels in all subjects and also calculated BMI ,HOMA-IR .We analyzed the relationship among resistin ,Non-Alcoholic NAFL and all above-mentioned profiles finally .Results ： The constituent ratios of the fatty liver and serum resistin level were significantly higher in Uygur than Han subjects .After adjusting of sex ,age ,BMI ,SBP ,DBP ,TC ,HDL-c ,LDL-c ,TG and HOMA-IR ,compared with the normal group ,the a serum resistin level in NAFL group was increased and has significant difference in Uygur .The prevalence of NAFL and BMI ,DBP ,TC ,TG ,HOMA-IR levels were increased while the resistin levels were increase .The results of logistic regression analysis suggested that after adjusting of sex ,age ,BMI ,SBP ,DBP ,HOMA-IR ,TC ,HDL-c ,LDL-c ,TG ,compared with the lowest resistin levels group , the OR value of NAFL of the second ,third group were 7 .048 and 8 .085 respectively ;the OR value of insulin resistance of the second ,third group were 2 .892 and 3 .699 respectively .After adjusted age ,sex ,SBP ,DBP ,TG ,TC , HDL-c ,LDL-c ,partial correlation analysis suggests that HOMA-IR was positive correlation to serum resistin level . Conclusion ：The higher resistin level is an independent risk factor for NAFL in Uygur .Resistin is positive correlation to insulin resistance .

关 键 词：脂肪肝 病理生理学 抵抗素 代谢 胰岛素抗药性 维吾尔族 

分 类 号：R575[医药卫生—消化系统]