miR146a基因多态性与早发型阿尔茨海默病的关联性研究  

Association of the miR146a polymorphisms with early onset Alzheimer disease

作　　者：崔理立[1] 蔡玉洁[1] 马国达[1] 李克深[1] 李友[1] 

机构地区：[1]广东医学院附属医院衰老与心脑疾病相关重点实验室广东医学院附属医院神经病学研究所,524001

出　　处：《神经疾病与精神卫生》2014年第1期9-11,15,共4页Journal of Neuroscience and Mental Health

基　　金：国家自然科学基金（81271214,81300929）;国家自然科学基金中美国际合作（NSFC-NIH）研究项目（81261120404）

摘　　要：目的 探讨miR146a的基因多态性与早发型阿尔茨海默病（EOAD）的关系.方法 本研究共纳入103例EOAD患者和100名健康对照组人群,采用SnapShot分型技术检测miR146a基因的rs2910164和rs57095329的多态性.结果 病例组的rs57095329位点的基因型和等位基因频率与健康对照组比较,差异有统计学意义（基因型P=0.027 0,等位基因频率P=0.004 2）,而rs2910164的病例组和对照组基因型和基因频率差异无统计学意义（基因型P=0.595 7,等位基因频率P=0.322 6）.结论 miR146a基因的rs57095329多态位点与EOAD的发病风险具有相关性,rs57095329的G等位基因是EOAD的发病风险的保护因素.Objective To investigate the potential association between miR146a polymorphisms and risk of early onset Alzheimer disease （EOAD）.Methods The present study recruited 103 patients with EOAD and 100 healthy controls.The Multiplex SnapShot was used to determine the genotype and allele frequencies of rs2910164 and rs57095329 polymorphisms of miR146a gene.Results There was a significant difference in the genotype and allele frequencies of rs2910164 between the EOAD subjects and controls （genotypes,P =0.027 0 ; Allele frequencies,P =0.004 2）.However,no significant association was observed between the rs2910164 polymorphism and EOAD （genotypes,P =0.595 7; Allele frequencies,P =0.322 6）.Conclusions The rs57095329 polymorphism of miR146a gene is involved in genetic susceptibility to EOAD,and the G allele is a protective factor from the risk of EOAD.

关 键 词：阿尔茨海默病 miR146a 基因多态性 

分 类 号：R541.4[医药卫生—心血管疾病]