罂粟碱开放血脑屏障动脉化疗96例恶性胶质瘤长期效果  

Papaverin injection for blood-brain-barrier opening in chemotherapy of 96 maligment gliomas

作　　者：薛洪利[1] 李震[1] 孙晓宇[1] 

机构地区：[1]沈阳军区总医院神经外科,110840

出　　处：《临床神经外科杂志》2014年第1期64-66,共3页Journal of Clinical Neurosurgery

摘　　要：目的 观察和分析罂粟碱可逆性开放血脑屏障动脉注药化疗恶性胶质瘤的效果.方法 对96例恶性胶质瘤病人经颈动脉穿刺注入罂粟碱可逆性开放血脑屏障后,动脉注入卡莫司汀（BCNU）进行治疗,连续观察20～23年.结果 96例中5年生存率25％,10年生存率11.45％,20年生存率10.4％.目前仍有10例生存,最长23年多.结论 罂粟碱可逆性开放血脑屏障动脉注药化疗恶性胶质瘤可作为术后化疗的一种方式.Objective To study the curative effects of open blood brain barrier by injecting papaverine. Methods 96 patients with malignant glioma were treated with blood brain barrier by injecting papaverine and observed for 20-23 years. Results Of 96 patients,5-year surviving rate was 25% ,10-year surviving rate was 11.45% ,20-year surviving rate was 10.4%. 10 patients survived and 23 years in longest. Conclusion The treatment of opening the blood brain barrier by injecting papaverine into carotid artery and injecting chemical drugs for malignant glioma can be a choose for postoperative chemotherapy.

关 键 词：恶性胶质瘤 动脉化疗 血脑屏障 

分 类 号：R739.41[医药卫生—肿瘤]