高强度聚焦超声致培养肿瘤细胞的温升效应  

Temperature Rising Effect of High Intensity Focused Ultrasound

作　　者：高尚梅[1] 赖春冬[1] 王智 

机构地区：[1]重庆市第一人民医院,重庆市400011 [2]重庆医科大学医学超声工程研究所,400016

出　　处：《中国超声医学杂志》2001年第1期4-6,共3页Chinese Journal of Ultrasound in Medicine

摘　　要：目的 :探讨高强度聚焦超声对肿瘤细胞的影响。方法 :观察人体卵巢上皮癌细胞受不同强度和时间的超声辐照后 ,肿瘤细胞的急性死亡率及肿瘤细胞的形态变化、增殖曲线和倍增时间。结果 :不同的生物学效应与 HIFU的声功率、照射时间呈正相关 ,一定强度的声功率下 ,照射时间愈长 ,其生物学效应越明显。结论 :高强度聚焦超声能灭活肿瘤细胞且能撕裂肿瘤细胞。Objective:To explore the effect of high intensity focused ultrasound(HIFU)on tumor cells.Methods:The mortality and morphologic changes of human ovarian epithilial carcinoma cells were observed after HIFU with different intensity and sonication duration.Results:There was positive correlation between biological effect and power of HIFU,focused domain and sonication duration.Under a definite power,the more time sonication spent,the more obvious biological effect existed.Conclusions:High intensity focused ultrasound can inactivate and dilacerate tumor cells.

关 键 词：高强度聚焦超声 人体肿瘤细胞 生物学效应 

分 类 号：R730.5[医药卫生—肿瘤]