不同剂量纳洛酮治疗脑梗死临床疗效对比分析  

Compared Analysis Clinical Effects of Different Doses of Naloxone Dosages on Cerebral Infarction

作　　者：马艳[1] 

机构地区：[1]北华大学附属医院,吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2014年第2期222-224,共3页Journal of Beihua University（Natural Science）

基　　金：吉林市科技局科研项目(2008022)

摘　　要：目的分析不同剂量纳洛酮在急性期脑梗死患者治疗中的临床效果.方法选取住院后确诊为急性期脑梗死患者156例作为研究对象,按随机原则将其分成观察组和对照组.每天分别给予小剂量(1.2 mg)和较大剂量(4.0 mg)纳洛酮静脉滴注,每10 d为1个治疗周期.观察治疗后的总有效率及呕吐、恶心、呼吸抑制等并发症的发生情况.结果治疗后,两组患者的总有效率比较没有统计学意义(P>0.05);呕吐、恶心、呼吸抑制和低血压等并发症的发生率比较,观察组明显低于对照组,差异具有统计学意义.结论在对急性期脑梗死患者的治疗中,运用较低剂量的纳洛酮临床效果并不低于较高剂量的纳洛酮,并且并发症较少,值得临床关注.Objective To study clinical effects of different doses of naloxone on cerebral infarction patients in acute phase. Method 156 cerebral infarction patients in acute phase were randomly divided into observation group and control group. All the patients were treated with the conventional therapy, and at the same time the patients in the observation group were given 1.2 mg naloxone and those in the control group were given 4.0 mg naloxone, one therapy period for 10 days. The total effective rate and the complications such as vomiting, nausea, respiratory depression and hypotension were observed. Results There is no significant difference in total effective rate between two groups （ P 〉 0.05 ） ; vomiting, nausea, respiratory depression and hypotension of patients in the observation group were much lower than those in the control group, and the differences are statistically significant. Conclusion In the therapy process of cerebral infarction patients in acute phase, the therapeutic effect of low dosage of naloxone is not worse than that of high dose of naloxone and may induce less complication, which is worth paying more attention.

关 键 词：脑梗死 纳洛酮 并发症 

分 类 号：R743.3[医药卫生—神经病学与精神病学]