党参等中药对胃粘膜的快速保护作用  

One Immediate Protective Effects of the Traditional Chinese Medicine Radix Codonopsis etc on Gastric Mucosa

作　　者：李林[1] 潘志恒[1] 王竹立[1] 叶美红[1] 张静琳[1] 徐继威[1] 

机构地区：[1]中山医科大学附属第三医院,广东广州510630

出　　处：《中国医师杂志》2001年第2期112-114,共3页Journal of Chinese Physician

基　　金：广东省中医药管理局基金资助课题! (N0 .98380 )

摘　　要：目的　为观察党参、大黄、丹参、疏肝调胃汤等中药对胃粘膜的快速保护作用及中药胃粘膜快速保护作用的普遍性。方法　采用先给大鼠胃饲药物 ,随后立即胃饲 2ml无水乙醇的方法 ,分别观察党参、大黄、丹参煎剂及疏肝调胃汤对大鼠胃粘膜损伤的影响。结果　⑴预先胃饲党参煎剂 10 g/kg显著抑制大鼠胃粘膜损伤 ,损伤抑制率为 79 9% ;⑵预先胃饲大黄煎剂 12g/kg ,损伤抑制率为 4 8 1% ;⑶预先胃饲丹参煎剂 12 g/kg ,损伤抑制率为 6 1 53% ;⑷预先胃饲疏肝调胃汤 6 g/kg ,损伤抑制率为 56 84 % ;预先胃饲疏肝调胃汤 12 g/kg ,损伤抑制率为 79 79%。结论　党参、大黄、丹参和疏肝调胃汤均对胃粘膜有快速保护作用 ,在单味中药中党参作用最短 ,丹参次之 。Objective This paper was to observe the immediate protective effects of Radix Codonopsis,Radix Rheum,Radix Salvia and Shu Gan Tiao Wei Tang on gastric mucosas and to discuss the universality of the immediate protection of Traditional Chinese Medicine.Method The drugs were given oral to rats,then the absolute ethanol 2ml were administered immediately to observe the effects of decoction of Radix Codonopsis,Radix Rheum,Radix Salvia and Shu Gan Tiao Wei Tang on gastric mucosal damage;respectively.Results ⑴The 10g/kg of Radix Codonopsis decoction pre-injected oral inhibited markedly gastric mucosal damage with 79 9% of the inhibitory rate.⑵The 12g/kg of Radix Rheum decoction was pre-injected oral,the inhibitory rate was 48 1%.⑶When the 12g/kg of Radix Salvia decoction was pre-injected oral,the inhibitory rate was 61 53%.⑷When the 6g/kg of Shu Gan Tiao Wei Tang pre-injected was oral,the inhibitory rate was 56 84%;When the 12g/kg of Shu Gan Tiao Wei Tang was pre-injected oral,the inhibitory rate was 79 79%.Conclusions All of the Radix Codonopsis,Radix Rheum,Radix Salvia and Shu Gan Tiao Wei Tang possessed the immediate protective effect on gastric mucosas.Among the onefold drugs,the effect of Radix Codonopsis is the strongest,the Radix Salvia is secondly and the Radix Rheum is last.

关 键 词：胃溃疡 中药 细胞保护 中医药疗法 

分 类 号：R285.5[医药卫生—中药学]