特发性正常压力脑积水患者的认知功能状况研究  

Research of cognitive impairment in patients with idiopathic normal pressure hydrocephalus

作　　者：李晓鹤 

机构地区：[1]武汉市汉阳医院神经内科,武汉430050

出　　处：《中国实用神经疾病杂志》2014年第5期13-15,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨特发性正常压力脑积水患者认知功能损害的特点。方法对20例特发性正常压力脑积水患者(A组)、21例轻度阿尔茨海默病患者(B组)及22例健康体检者(C组)进行神经心理学测试,并对测试的工作特征曲线进行分析。结果 A组与B组患者各项目的神经心理学测试成绩分别与C组相比,差异均具有统计学意义(P<0.05);A组额叶功能评定量表评分、言语流畅性评分、斯特鲁普色词测验卡片A耗时数、斯特鲁普色词测验卡片B耗时数、斯特鲁普干扰量及积木测试评分等与B组对比,差异均具有统计学意义(P<0.05);斯特鲁普色词测验卡片A耗时数、斯特鲁普色词测验卡片B耗时数、斯特鲁普干扰量对A组诊断的工作曲线下面积分别为0.911、0.921及0.878。结论特发性正常压力脑积水患者均有不同程度的注意力、执行功能、记忆力及视空间能力的损害,执行功能的损害最严重。Objective To explore the features of cognitive impairment in patients with idiopathic normal pressure hydro- cephalus. Methods 20 patients with idiopathic normal pressure hydrocephalus（group A）,21 mild Alzheimer＇S disease patients （group B） and 22 healthy volunteers（group C） were measured by neuropsychological test. These measures were analyzed by re- ceiver operator characteristic curve. Results Each objective neuropsychological test scores of group A and group B were statisti- cally significant, compared with group C respectively （P〈0.05）. There were significant differences between group A and group B in Frontal Assessment Battery, Verbal Fluency Test, time of complete Stroop Color Word Test Card A, time of com- plete Stroop Color Word Test Card B, time of Stroop Interence Effects scores and Block Design Test scores（P〈0.05）. The are- as under the receiver operator characteristic curve for diagnosis of group A by time of complete Stroop Color Word Test Card A, time of complete Stroop Color Word Test Card B and time of Stroop Interence Effects were 0. 911,0. 921 and 0. 878, respec- tively. Conclusion Patients with idiopathic normal pressure hydrocephalus are impaired in varying degrees of cognition invol- ving memory, attention, executive function and visuospatial ability, the most prominent of which is the executive dysfunction.

关 键 词：正常压力 脑积水 认知障碍 执行功能 

分 类 号：R742.7[医药卫生—神经病学与精神病学]